Targeting a complement serine protease in vascular disease

In spite of major advances in our knowledge and better treatments, heart attacks, strokes and blood clots in the legs and lungs, continue to major causes of disability and death. Recent studies reveal that a protein (a so-called "serine protease") in our blood, when increased, may heighten the risk of excess blood clot formation in our blood vessels. Our studies are designed to determine how this protein works, and if by blocking its activity, we can prevent excess blood clotting. Our research program may uncover a more effective way to prevent blood vessel disease.

Intern: 
Alexander Leatherdale
Faculty Supervisor: 
Edward Conway;Edward Pryzdial
Province: 
British Columbia
Partner University: 
Discipline: