Towards the development of a bone substitute-based targeted drug delivery tool to treat bone metastasis
We aim to develop human bone extracts mixed with commercially available bone putty and prepare customized 3D print materials, both of which are infused with anti-cancer drugs. These bone substitutes could be used to fill and stabilize the large empty spaces and to locally deliver anti-cancer drugs that kills any remaining tumor cells and promote bone healing following tumor resection in patients with bone metastasis. We also aim to establish a 3D bone metastasis-like model that will be used to test the drug delivery from bone substitutes. J & J could adopt and manufacture these new treatment modalities and commercialize them for hospitals to treat patients with bone metastasis.