Treating the Untreatable: Targeting Paediatric Brain Tumours with Multi-omics and Drug Discovery - Year two
Brain tumours, including ependymoma, are some of the most difficult cancers to treat. Although the past few years have seen many exciting advances in characterizing these brain tumours, there are few effective therapies available for patients, many of whom are children and young adults (and for whom long-term side effects can be extremely damaging). Until very recently, research in this area has been hampered by a complete lack of cell lines and animal models. Fortunately, the Taylor Lab at SickKids have successfully developed novel tumour culture methods to get these difficult cells to grow—producing the required model systems.
We now aim to use these new model systems to fully investigate the development of ependymoma disease and screen for compounds in the Structural Genomics Consortium (SGC) library that can be used to treat patients with this disease.TO BE CONT'D