UVPD of DMS-MS-selected SARS-CoV-2 peptides
Differential mobility spectrometry (DMS) is a technique that is used for the analysis of chemicals by separating complex gaseous mixtures under the influence of an electric field. It is a widely used technique and is successfully deployed in many areas, including drug and explosives testing at airports. In analytical laboratories, it can be used to separate peptides – the components that make up proteins and viruses. However, analysis of data from these experiments can be ambiguous and difficult to interpret. We propose to eliminate that ambiguity by simultaneously measuring those chemicals’ response to UV light after they are separated by using DMS. Their response will help us to identify peptides directly, based on their unique interaction with light.