In Vivo Reprogramming of Spiral Ganglion Glial Cells into Primary Auditory Neurons
Sensorineural hearing loss involves damage to hair cells, the sensory transducers of the auditory system, and/or the auditory neurons that transmit this information to the brain. Once these cells are lost the body does not naturally regenerate them. Elsewhere it has been shown that cells of one type may be converted into another cell type. This project involves using viral expression of select transcription factors in the spiral ganglion to convert resident cells into new auditory neurons to restore hearing.