This proposed research project is about development of new bone-targeting drug called PTHPEG- BP, this new compound will overcome shortages of current clinical peptide hormone PTH, and show better treatment efficacy and lower price then the latter; several new technologies will be used on research of this PTH, such as micro Positron Emission Tomography (PET/CT), and several of its characteristics will be identified such as structure, bioactivity, and metabolism inside body.
Stockpiles of scrap tire grow larger every day in Alberta due to heavy industry. Safe and healthy disposal of scrap tires requires costly municipal landfill space. Using tire derived aggregates (TDA) for construction applications such as road embankment and insulation layers is of great attention and interest to Alberta’s government. Frost penetration beneath the pavement causing frost heave in winter followed by spring thaw weakening is one of the factors that affect the base layer thickness in cold climates.
Learning Systems are among the most popular e-learning tools in today’s education and training. Most e-Learning systems do not take into account individual aspects of learners (e.g., their goal, experiences, existing knowledge, learning style etc.).The primary goal of the proposed research is to offer rich adaptivity by combining information from a learner’s profile (e.g. levels, goals, learning style, cognitive abilities etc) with the information from other learners sharing common interests.
Quantitative interpretation of magnetic data through inversion for general distributions of magnetic susceptibility has played an increasingly important role in mineral exploration in recent years. The goal of the proposed project is to develop efficient and robust computational simulation tools for the inversion of magnetization at a specified depth using ground/airborne magnetic data.
The goal of the project is to evaluate the pedagogical impact of Pearson’s Knewton-enhanced MyLab products in comparison to their regular MyLab products. Our focus will be on Knewton-enhanced MyMathLab and MyStatsLab. This project will deploy Knewton’s adaptive learning technology in our Data Analysis in Psychology course, a course dominated by second year students (approximately 90%). The course is a requirement for all Psychology students and offered every Fall semester. The assessment will occur in Fall 2013 and will provide data from over 300 students.
The objective of this project is to design a Visual Systemic ‘Risk Map’ as one possible prototype to address some of the issues of risk identification and analysis in the context of global financial systems. We propose the design concept of the ‘Risk Map’ using principles of Cognitive Systems Engineering (instrumental papers in this field are Rasmussen et al. 1994; Vicente and Rasmussen, 1990; Woods and Roth, 1988), which is suited to engineering for complex systems.
There are two interconnected processes required for this project to succeed: a process of consultation and engagement of the public and stakeholder groups, and the more technical development of measures. Both areas involve key methods for applied research and knowledge mobilization within the social sciences.
Recent research at the University of Calgary has focused on shear walls and on evaluating the influence of various parameters on in-plane shear capacity. The reason for this is that, for example, while it is recognized by most researchers that compression on walls increases the shear strength of masonry, the quantification of this effect has been reported to vary from 40 to 70% [1,8] and the factors adopted by various design standards range from 0.25 up to 0.4.
Our immune system Is designed to protect us from harmful agents. It must initiate a rapid potent inflammatory response to eliminate invading pathogens. Although similar to the eradication of pathogens, the inflammatory response can also occur following a sterile injury and is required for tissue repair and wound healing. This includes trauma, ischaemia-reperfusion injury, autoimmunity or burn induced injury that occurs in the absence of any microorganisms.
Prolonged morphine treatment is known to cause an up-regulation of ORL1 receptors in the spinal cord (12, 13), which in turn is believed to contribute to the development of morphine tolerance by altering ?-opioid receptor mediate modulation of N-type calcium channels. Indeed, ORL1 antagonists can reverse the development of tolerance, and ORL1 knockout can mediate resistance to tolerance with no changes on the acute analgesic effects of morphine (14, 15). Our lab has shown that ORL1 receptors and Cav2.2 channels form a physical signaling complex that results in tonic G??