Development of a smartphone-based sensor system to assess everyday movement, speech, and sleep for stroke recovery Year One

Following a stroke, the rehabilitation gains achieved in intensive therapy are often lost without sustained follow-up. The long-term objective of the project is to extend the reach of the health team (physicians, therapi sts, caregivers) following hospital discharge to continue therapy using mobile devices. As a first step, the objectives of the planned project are to:

1) develop clinically meaningful metrics related to the quantity and quality of everyday movement, speech, and sleep from body-worn sensor data,

2) to design and fabricate system prototypes for testing, and

Role of nocturnal fluid redistribution in the pathogenesis of sleep apnea Year One

when lying down to sleep and accumulates in the neck or lung; which could be a major contributor to the development of sleep apnea in HF patients. Therefore, we aim to determine whether: 1) the relative degree of fluid shift into the neck and lungs at night is associated with the severity of sleep apnea; 2) the respiratory sounds recorded from the neck and lungs can be used to estimate the amount of nocturnal fluid accumulated in the neck or lungs. If so, a new approach for the therapy of sleep apnea would be to prevent fluid accumulation in the legs during the day.

Development of an Electrodynamic Simulation Toolbox for Nanophotonics

Finite Difference Time Domain (FDTD) simulations allow researchers to model complex devices and systems based on integrated micro/nano structures. The electrodynamic behaviour predicted by FDTD simulations match very well with the real physical systems, which significantly accelerates the development of novel devices. However, there are limitations in existing FDTD techniques to model metal nanoparticles on sub-100 nm length- scales, which are of great interest to research and industry.

Regulation of T-type calcium channel activity by targeting channel trafficking – a novel approach for pain management Year two

Current therapies to manage pain either result in side effects or are insufficient and the associated medical costs and loss of work days come pose a tremendous socioeconomic burden. We recently showed that T-type channel activity is aberrantly regulated in inflammatory and neuropathic pain by the deubiquitinase USP5, and we have begun to explore this mechanism as a new therapeutic avenue based on interfering TAT peptides. We now plan to test our TATpeptides in diabetic neuropathy and inflammatory bowel pain.

Advanced Adaptivity and Personalization in Learning Systems through Collaborative Recommendations Year Two

Learning Systems are among the most popular e-learning tools in today’s education and training. Most e-Learning systems do not take into account individual aspects of learners (e.g., their goal, experiences, existing knowledge, learning style etc.).The primary goal of the  proposed research is to offer rich adaptivity by combining information from a learner’s profile (e.g. levels, goals, learning style, cognitive abilities etc) with the information from other learners sharing common interests.

Tests for models used in Actuarial and Risk management and Economic forecasting

In Actuarial Science and insurance, models are often used to assess risk using factors such as age, level of education, gender, environment, etc. In practice, there might be unobserved factors.  When data are gathered, the accuracy of these models should be investigated. If the model is not well fitted by the data, subsequent influences could be badly wrong. In this proposal, we shall examine tests to check the model validity. In addition, we examine the effect on inference of a failure in the model.

Radiochemistry for the Pharmacokinetic Evaluation of Novel Bone-Targeting Peptide Hormone Derivatives

This proposed research project is about development of new bone-targeting drug called PTHPEG- BP, this new compound will overcome shortages of current clinical peptide hormone PTH, and show better treatment efficacy and lower price then the latter; several new technologies will be used on research of this PTH, such as micro Positron Emission Tomography (PET/CT), and several of its characteristics will be identified such as structure, bioactivity, and metabolism inside body.

Evaluation of Application of Shredded Tiresas Insulation Layers for Highways in Alberta

Stockpiles of scrap tire grow larger every day in Alberta due to heavy industry. Safe and healthy disposal of scrap tires requires costly municipal landfill space. Using tire derived aggregates (TDA) for construction applications such as road embankment and insulation layers is of great attention and interest to Alberta’s government. Frost penetration beneath the pavement causing frost heave in winter followed by spring thaw weakening is one of the factors that affect the base layer thickness in cold climates.

Advanced Adaptivity and Personalization in Learning Systems through Collaborative Recommendations

Learning Systems are among the most popular e-learning tools in today’s education and training. Most e-Learning systems do not take into account individual aspects of learners (e.g., their goal, experiences, existing knowledge, learning style etc.).The primary goal of the  proposed research is to offer rich adaptivity by combining information from a learner’s profile (e.g. levels, goals, learning style, cognitive abilities etc) with the information from other learners sharing common interests.

Developing efficient computational simulationtools for geophysical applications

Quantitative interpretation of magnetic data through inversion for general distributions of magnetic susceptibility has played an increasingly important role in mineral exploration in recent years. The goal of the proposed project is to develop efficient and robust computational simulation tools for the inversion of magnetization at a specified depth using ground/airborne magnetic data.

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