Developing implantable scaffold for bone regeneration with healing enhancement by local drug delivery and sustained drug release

Over 3 million Canadian suffer from bone disease resulted from trauma, tumor removal and cancer and the number increasing with aging population every year. We plan to use hydrogels to create bioactive scaffold using 3D bioprinting extrusion method with potential for local drug loading and slow drug release for bone regeneration. We develop bioinks with proper mechanical strength and fidelity to keep the shape of the scaffold. I this work with incorporate bone growth factors to accelerate repair of bone defects.

Role of Ribosomal Protein Ubiquitination in Chemotherapy- and Stress-induced RNA disruption in Tumour Cells

We have observed that chemotherapy agents can induce RNA degradation in tumour cells, a phenomenon called “RNA disruption”. Interestingly, we also found that high tumour RNA disruption after 2-3 cycles of chemotherapy predicts for complete tumour destruction after treatment and improved cancer patient survival. We and Rna Diagnostics, Inc. are using this knowledge to identify patients with non-responding tumours early in treatment, who might benefit from discontinuing chemotherapy (and its side effects) and moving on to alternate treatments.

Frailty risk detection from primary care electronic medical records

Older adults with frailty are at high-risk of declines in their health and do not bounce back as well as their non-frail counterparts. These patients are among the highest users of health care because they end up in crises and go to emergency, are hospitalized, or die. But, if frailty is detected and managed earlier, before negative events occur, it can improve patient outcomes and decrease health system costs. Currently, frailty detection relies on tools that take added time and resources that family doctors do not have.

Community Based Mental Health Supports for Men from Ethnoculturally Diverse Communities.

This community project will train men from diverse ethnocultural backgrounds and support them in leading well-being groups with men from their communities. Evaluations from past projects have underscored the importance of engaging men in conversations of well-being, healthy relationships, and violence-prevention. This includes the need for further outreach to support men in accessing services and address intersectional and system barriers as part of an overall strategy for mens’ well-being and violence prevention.

Developing a Sensitive and Quantitative Opioid Detector for Use in a Clinical Setting

The opioid epidemic is a serious health crisis in Canada, North America, and globally and has worsened during the COVID pandemic. Opioid treatment strategies are at the forefront of efforts to tackle this crisis. To improve the replacement therapy currently used, an estimate of tolerance is required. This proposal takes an existing proof-of-concept opioid detection device and adapts it for use in the clinical setting to address this challenge.

Assessment of environmental and economic sustainability of peri-operative patient warming strategies in hospitals

Hospitals use different warming techniques for surgery patients to prevent them from hypothermia, i.e., becoming cold during their operation. Many warming techniques are commonly available and used but studies on their holistic environmental impacts are lacking. The overall environmental impacts and economic costs of products or services can be assessed using life cycle assessment (LCA) and life cycle cost analysis (LCCA), respectively.

Remote Supports as a Service Delivery Option for Individuals Accessing Community Living Services

Many services including health services are now offered remotely through live 2 way communication from the practitioner’s office to the patient’s home. Community Living Society, Inclusion Langley, Richmond Society for Community Living, and Spectrum Society for Community Living, plan to see how this model might work in our programs that support individuals who have a developmental disability to live independently in community.

Supporting 2SLGBTQI+ Organizations Through Research and Advocacy

The Enchanté Network is Canada’s largest network of 2SLGBTQI+ organizations, connecting nearly 200 members in every province and territory. The Enchanté Network’s Resourcing 2SLGBTQI+ Communities Initiative supports a Postdoctoral fellow in carrying out a community-driven model for research collaboration, public policy engagement, and social innovation in the areas of gender, sexuality, and culture. In particular, it shines a light on the funding available to support 2SLGBTQI+ services and organizations.

Psilocybin dosing and adult neurogenesis

Psilocybin is a psychedelic compound that alters states of consciousness to allow free imagination and insightful creativity. Its ability to induce complex behavioral and psychological changes has led to its resurgence in psychedelic-enhanced psychotherapy. Despite positive clinical efficacy from ahandful of trials, an optimal (or even variable) treatment paradigm has yet to be established.

Developing an Application to Facilitate Health Practitioner-to-Patients eConsultation

Despite the advances in medical science over the years, a great number of the world population still lacks access to basic healthcare. The health disparity between people in low resource settings and developed countries cannot be overemphasized. The disparity in health between developing and developed countries is evident in their life expectancy. However, the current COVID-19 pandemic has taught us that our health is interconnected, and we are as healthy as the weakest link.

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