A comparison of finite element model-predicted brainstem strains between injurious and non-injurious laboratory reconstructed football impacts

Studies of concussive events have shown that the response of the brain during an impact may not be the most reliable predictor of concussion, since the injury may be more closely related to the forces affecting the brainstem. A laboratory crash test protocol was developed to simulate player-to-player collisions in contact sports using crash test dummies and the impact forces on the dummy head were calculated.

Synchronization of ovulation to improve the efficiency of an in vitro embryo production/embryo transfer program in commercial operations in cattle - Year two

In vitro embryo production and embryo transfer (IVP/ET) is a technique that has been developed in cattle for genetic selection to enable rapid improvement in commercially important traits. Technological advances have resulted in a significant increase in the commercial use of IVP/ET in recent years, and have made this one of the fastest growing sectors in the dairy industries. However, pregnancy rates following the transfer of IVP embryos are lower than that of in vivo produced embryos.

Investigating the Change Management Process in High Performance Sports Organisations Related to Performance Management

Organisational change is part of life for sports teams, however, research suggests that despite how often change initiatives occur, the success rate for organisations achieving their desired outcomes is less than 30%.
The aim of the study is to investigate how top level sports organisations manage change and to compare the different approaches adopted by various sports in countries around the world.
This study will interview sporting directors and general managers from around the world in order to:
1) identify how sporting directors identify, research and plan change initiatives, with a compar

Development of novel crop protection technologies using Canadian microbes

Development of new and improved plant biotimulants through the combination of soil-borne bacteria like Pseudomonas chlororaphis PA23 should provide new opportunities for crop improvement in the Canadian Agri-Food market. The proposed MITACS Accelerate project will support collaborative research and develop synergies between industry and scientists at the University of Manitoba to investigate the effect an an established plant growth promoting bacteria, PA23, in the presence and absence of one of Stoller Enterprises most well-known biostimulant product, BioForge.

Numerical Simulation and Experimental Validation of a Large Scale Industrial Biochar plant

Slow pyrolysis is a process to convert biomass residues to valuable biochar products, which are used in agricultural, wastewater treatment, animal feed, carbon sequestration etc. IRSI focused on identifying optimal pathways for converting biomass into high quality biochar with maximum energy efficiency and minimal environmental degradation. This project focusses on modelling and simulation of a large-scale biochar reactor in order to enhance the efficiency of pyrolysis processes and increase the reliability of biochar products for the global market place.

Developing Single Use Performance Enhanced Raman (SUPER) spectroscopy probes for bioprocessing reactions

Raman spectroscopy is a powerful analysis technique in which a chemical sample is illuminated by a laser and the molecular identity of the sample is revealed by measuring the precise wavelength shifts of the reflected laser photons. Raman methods are being adopted in many different business sectors, but they are particularly well-suited to the requirements of the bioprocessing/biopharma industry, where many different chemical constituents, namely peptides and sugars, must be precisely quantified in real time to optimize the growth and yield of the cell cultures.

Determination of optimal conditions for the large-scale production of astaxanthin in algae

Astaxanthin is a high-value natural product that is produced by a number of strains of algae. Astaxanthin and related carotenoids such as leutein and zeaxanthin, all derived from beta-carotene, have been demonstrated to have positive health benefits when taken as a dietary supplement. The Myera Group, a Manitoba biotechnology start-up company, has as a primary goal the production of astaxanthin for the commercial market.

Modulation of human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) ion channels and transporter activity, measured by atomic absorption spectroscopy (AAS)

During human clinical trials, a large percentage of candidate drugs fail because they are unsafe or ineffective. Even when preclinical cell and animal studies seem positive, problems occur because drugs tested with these models are often not predictive of what happens in humans. Many drugs, including non-cardiovascular drugs, target ion channels of the heart (membrane proteins through which heart cells conduct electrical currents), which can potentially result in lethal arrhythmias.

Cannabinoid Ensemble on Cerebrovascular Physiology: A Dosage Escalation Study

The proposed research will examine the effects of different concentrations of medical cannabis (high cannabidiol (CBD)/low tetrahydrocannabinol (THC) on brain and heart physiology. CBD is ‘non-psychoactive’ and has shown to be anti-inflammatory, anti-depressive, and neuroprotective. However, limited clinical research is available on safe dosages for the human brain. Normal control participants without pathological or psychological disorders will undergo a dose escalation study to determine the safety and efficacy of high CBD/low THC.

Detection of insulin using a novel capturing system

Insulin is a hormone released from the pancreas, which controls the level of glucose in blood. Diabetes is a disease characterized by a lack of insulin production or impaired insulin action. Here, we propose the development of a novel system based exclusively on the measurement of insulin using capturing molecules with high affinity to insulin. This method will provide an affordable and simplified method to be used not only in point of care but also by the patient at home.

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