Mycobiota dysbiosis in colitis-associated colorectal cancer

A higher incidence of colon cancer is reported in populations consuming high amounts of red meat, as well as in patients with inflammatory bowel disease, where gut bacteria participate in the development of inflammation. We found that dietary supplementation with heme, an element found at high levels in blood, is detrimental to gut health and it fosters the growth of harmful bacteria. In this project, we propose to establish new procedures for both the manipulation of the gut bacteria (microbiota), as well as its characterization using a new state of the art sequencer.

Enhancing performance in Canadian athletes: A novel and integrated approach to neurofeedback and heart rate variability biofeedback training in the daily training environment

Two essential factors of sport performance at the elite level of sport are the ability to focus on the correct aspects at the correct time while ignoring irrelevant distractions and effectively managing anxiety in the very stressful environment of a World Championship or an Olympic Games.

Nutritional and exercise recovery strategies to improve sports performance in young athletes – the need for protein

The purpose of this multi-project study is to investigate the effects of two different doses of protein supplementation following exercise training on muscle damage and inflammation, as well as on post-recovery exercise performance in young swimmers. Sub-project 1 examines whether whey protein supplementation following a training session enhances exercise performance and affects post-exercise muscle damage and inflammation.

Profiling Microbial Volatile Organic Compounds (MVOC’s); Progress Toward Detection of Various Mould Species via Gas Chromatography-Mass Spectrometry

The purpose of this research will be to analyze microbial volatile organic compounds for the purpose of the development of an analytical method for the detection and speciation of moulds in an indoor environment.

Detection and characterization of biodegradable polymeric biomaterials

Biodegradable polymeric biomaterials have been used extensively for medical applications such as implants, drug/gene delivery, and scaffolds. To determine the end applications, the molecular characteristics of these polymeric biomaterials are important which must be characterized. The development of reliable and fast analytical tool to detect, separate and characterize polymeric biomaterials in medical devices and drug formulations is still challenging.

Development of the Tat-GluN2BCTM peptide as a novel therapy for acute myocardial infarction

Acute myocardial infarction (commonly known as a heart attack) is a major disease of the cardiovascular system and a leading cause of death and hospitalization in North America. It results in 7.4 million deaths globally per annum. Current clinical medications only prevent the disease but cannot cure it after a heart attack occurs. Scientific evidence suggests that DAPK1 is a vital protein that can cause heart damage during a heart attack, and I have created a compound that is able to reduce the level DAPK1 in the heart so as to prevent heart damage.

Impact of a cognitive intervention program for adults with traumatic brain injury (TBI)

Cognitive impairments are the most common long-term challenges after traumatic brain injury (TBI). There is very little research on interventions to improve cognitive function after brain injury. The goal of this project is to evaluate whether and how an intensive cognitive intervention program (Arrowsmith program) may stimulate positive changes in the brain. We have already started this program and showed that after 3 months of intervention, there were small changes in both brain and behaviour.

Development and Assessment of Vitamin-Enriched Granule Extracts from Egg Yolk

The chicken egg represents an excellent source of nutrients, and the composition of the egg yolk can further be enhanced through modifications to the laying hen diet. While enhanced shell eggs are primarily sold as specialty eggs, an opportunity exists to add further value through the use of novel extraction technologies. The proposed research project will combine existing expertise in egg yolk enhancement with expertise in liquid/protein processing and extraction techniques.

Development of colony-specific genetic markers for murres hunted off Newfoundland and Labrador

Thick-billed murres from breeding colonies throughout the North Atlantic, and common murres from colonies throughout the northwest Atlantic winter off Newfoundland, Labrador and Greenland where they are the object of an annual hunt. The winter murre or ‘turr’ hunt is an important part of the culture of coastal communities, and is protected under Canadian legislation. The colony of origin of hunted murres is unknown, although it is necessary to assess the impact of the hunt on specific colonies. The hunt could target colonies that are suffering great declines.

Smart mutational exploration of the CalB lipase active site using a combination of virtual screening and iterative saturation mutagenesis

The company Odyssée Biotech specializes in the production of natural flavors and fragrances using innovative enzyme technologies. Using natural enzymes allows the enterprise to produce highly pure ingredients in mild conditions with a natural label. This green approach also makes this technology highly competitive and environmentally sustainable relative to other production methodologies employed in the industry. The strawberry and ice mint flavors are priority target products in the food and flavoring industry, but they are hard to produce using currently available enzymes.