Multi-biomarker test for the management of acute cardiac transplant rejection

The high incidence of acute organ rejection following heart transplantation poses major problems for patients, clinicians, and the healthcare system. A major clinical challenge in this regard arises from the difficulty of accurately

Refinement of a Bioelectric Sensor to achieve real-time quantification of BOD

The necessity of cost-efficient and reliable wastewater treatment processes has increased in order to meet more stringent levels of environmental regulations, increased system reliability requirements and tightening operational budgets. To aid in meeting these operational goals, a strong market for low-cost, high-fidelity sensor technology that can relay real-time information to system operators on all aspects of wastewater treatment system performance has developed.

Oncolytic HSV-1 (oHSV-1) for treatment of prostate cancer

This project is to use genetic engineered “cold-sore” virus to treat prostate cancer. The virus is engineered to reduce its toxicity to normal tissues but can specifically attack and kill tumour cells. Meanwhile, the virus releases a group of anti-tumour immune stimulating factors to activate immune system to eliminate prostate tumour. This project will use a unique prostate tumour mouse model to test the virus.

Linking microbiome to eco-industrial function: the in silico and metagenomic exploration of microbial dark matter and taxonomic blind spots - Year two

The collection of bacteria and archaea in an ecosystem is termed the microbiome. This microbiome is critically important to the structure and function of essentially any ecosystem, providing many ecosystem services, such as growth promotion, nutrient turnover, and impacts on organismal health. The vast majority of these organisms, however, are unknown to science for a variety of reasons. Recent advances in high-throughput DNA and RNA sequencing of environmental samples provide a significant data resource to help understand these organisms.

Development of agent-eluting bio-absorbable scaffold suitable for animal implant

Micro-chip implantation provides a reliable, cost effective and less painful method of reuniting the lost pets with their owners. However, the formation of tumors and inflammation at the micro-chip implant sites has been observed in companion animals as well as rats and mice. Therefore, there is an emerging need for alternative material to coat or encapsulate the micro-chips to control the inflammatory reaction after the implant and the potential tumor formation.

The role of cyclodextrins in repairing dysfunctional lung surfactant

My work will provide an important insight of the newly developed S1229. Cyclodextrins (S1229) are cyclic molecule composed of 7-sugars, with a unique structure. S1229 forms a hydrophobic core, which interacts with cholesterol and phospholipid by-products and removing them from the membrane. SolAeroMed has shown that S1229 was able to repair lung surfactant function. Lung surfactant is protein-lipid mixture covering the air-water interphase in the lung. Surfactant is an essential component of healthy lung function and without it, breathing would be near impossible.

Digital Media Project: Affecting attention and emotion in a digital world

Human history is punctuated by new innovations that reshape the way people interact and process information, (e.g., the telegraph, the telephone, radio and TV). We are in the midst of a digital revolution, and old theories and methods for understanding and shaping the way people process information are woefully inadequate. This is evident both in the information overload that we in society are experiencing today, and in the inability of many companies to make themselves heard above the digital din.

Development of a microfluidic blood-brain barrier model for drug screening and testing

"Poor efficacy and unpredictable toxic effects are leading causes of removal of a drug from the market. Many drugs act unpredictably in patients because they are tested in labs using cells grown in plastic dishes and animals that poorly mimic humans.

An analysis of Delivra LivSport PreWorkout Cream combined with oral creatine to improve muscular performance and alter arterial stiffness

Creatine is a supplement known to improve performance over repeated high intensity exercise, seen in most sports. Typical creatine supplementation involves ingesting large amounts of the supplement, leading to side effects of weight gain and GI distress. Delivra™has formulated a new way to supplement creatine through a topical cream applied to the legs, which can potentially eliminate these side effects. This research will test this new creatine cream compared to oral ingestion to determine if it can improve high intensity performance, by generating more power and reducing fatigue.

Tumor engineering of biomaterial based cancer models for drug screening

The intern will use the company’s proprietary biomaterials to create tumors using cancer cells. These tumors can be used as an alternative to animal testing for cancer drugs. These cancer models will cost a fraction of the cost of animal models and can be tested using existing pharmaceutical techniques and equipment. The intern will develop a process to create tumors, then test existing drugs on the model to see how it compares to human and animal testing results.

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