Somatic cell reprogramming as a tool for the conservation of genetic resources from endangered species

Conservation of endangered species has become increasingly urgent. This is evident given the rate of species extinction by 100 to 1000-fold, and global biodiversity has decreased. With current climate changes, these concerns will only grow. Assisted reproductive technologies can play a vitalrole in endangered species conservation. Many approaches are currently being utilized or explored, including animal cloning. Unfortunately, cloned animals are not genetically pure and therefore, are not valuable for use in breeding programs.

Neuroimaging biomarkers of Parkinson’s disease identified through brain, brainstem and spinal cord imaging

In the current functional and structural neuroimaging project, we aim to identify functional and structural changes that correlate with disease presence and its severity  staging) and that can serve as a basis for future development of PD neuroimaging biomarkers. To achieve this objective we will use our expertise in functional neuroimaging of the cervical spinal cord (CSC), brainstem and brain (simultaneously), as well as in micro-structural neuroimaging of the spinal cord.

Visualization of lipid and protein deposition on contact lenses in a sophisticated in vitro eye-blink model

Contact lens discomfort is one of the primary reasons that cause people to stop wearing them. The discomfort may be due to the buildup of tear film components on the lenses during lens wear. The purpose of this project is to understand where most of the tear film components are depositing on the lens, such as the back or front of the lens. These findings will help researchers and companies develop better and more comfortable contact lens materials in the future.

Application of advance signal and image processing to develop objective diagnostic and monitoring technologies as well as predicting the response to treatment for Alzheimer's disease

An ongoing study in Winnipeg is investigating the possibility of using repetitive transcranial magnetic stimulation to help treat the cognitive and memory declines in Alzheimer's disease. The objective of this project is to analyze in detail the current results of this study. We will look for connections between MRI scans of the participants and their response to the treatment. We will also look at anxiety and resting motor threshold (a measure of how sensitive they are to our treatment device), to see how they change the effectiveness of treatment.

Hybrid biocatalytic valorization of lignin to green aviation bio-jet fuel (ligno-jet fuel) and bio-BTX aromatics

‘Sustainable biofuels’ refers to the fuels produced from biological resources such as plant/forest biomass. The suggested tailored biocatalytic processes could enable sustainable production of drop-in ligno-biojet fuel by using renewable resources, including forest biomass. The pulp mill biorefinery side-streams such as lignin extracted from black liquors are relatively inexpensive, widely available and attractive sources for biorefining. The main bioprocessing steps for production of bioject fuel include pretreatment, fermentation, hydroprocessing and oligomerization.

Photoacoustic remote sensing microscopy for pre-clinical and clinical applications

There is a desperate need for a fast, non-contact, non-invasive, safe and accurate technique that can measure oxygen saturation, oxygen metabolic activity and multilayered histology-like information. Oxygen saturation and oxygen metabolic activity play a vital role in understanding several diseases including early tumour and vision loss diagnosis and treatment. Additionally, when the oncologic care team must to remove a tumour, it is essential that no malignant tissue left behind.

Development and Optimization of Advanced High-Throughput Behavioural Testing Platforms for the Screening of Mouse Models of Schizophrenia

Operant chambers equipped with touchscreens are a new technology that has been used for the mass behavioural phenotyping of rodent models of neurological disease. These chambers have the potential to make behavioural testing more reliable, faster, and translationally valid to human cognitive testing. To further increase the utility of these systems, technology capable of tracking animal behaviour in the chamber will be integrated into the operant system.

Developing novel varieties of canola, rice and alfalfa with improved cell wall characteristics

Biobased products, mostly derived from plant biomass, have the potential to improve the sustainability of Canada’s natural resources and environmental quality while competing economically. Plant biomass, composed primarily of cell walls and modification of cell wall properties has the potential to improve biomass conversion to biobased products such as biofuels as well as improve feedstock quality in forage crops. Progress towards achieving this goal is currently impeded by a lack of knowledge of how cell walls are assembled and how their structure affects the processing of biomass.

The design and fabrication of a novel mitral heart valve for catheter-based insertion

The aim of this collaboration is to produce a novel design of percutaneous mitral valve that utilizes the synthetic cryogel material developed at the Heart Valve Performance Laboratory, UBC Okanagan campus for the valve leaflets, along with different anchoring mechanisms to develop an optimized option for testing. The proposed design will be made for either the transseptal, that being a puncture between the right atrium and left atrium to give access to the native mitral valve, or the transapical approach, that being entering through the apex of the heart into the left ventricle. TO BE CONT'D

Development of a Diagnostic Screening Platform for Quantitative Detection of Drugs in Saliva

Drug-impaired driving represents a significant and increasing threat to the safety of Canadians and there is an urgent need for a convenient, instantaneous and accurate road-side evaluation technology for impaired driving. Current solution for roadside drug testing includes a device that is still just a qualitative indicator. Quantitative detection of drugs currently require expensive equipment, dedicated infrastructure and specialized laboratory personnel. To address this problem, eye3concepts inc.

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