Optimization and GMP (Good Manufacturing Practices) translation of GLIDE (Guided Lymphocyte Immunopeptide Derived Expansion) manufacturing process

Leukemia, lymphoma and other forms of blood cancers are still largely diagnosed every year in Canada. These diseases constitute the second leading cause of cancer related death in young adults and the sixth in adult. The five-year survival rates still range between 42% and 85%. Currently, the main treatment is a stem cell transplantation which unfortunately do not prevent lethal relapse. The goal of this study is to develop and improve a novel cellular therapy aiming to limit and prevent relapse of hematological malignancies.

CardiAI Point-of-Care Device for High-Caliber and Rapid Diagnosis of Biomarkers from Blood of Patients for Early Heart Failure Detection

The aim of this research and development project is to design and develop a bedside point-of-care device to be equipped with the CardiAI’s machine learning technology for heart failure management. Our POC system will include disposable cardiac biomarker strips and an electronic reader.

Physiotherapy balls with pressure sensor

Today, physiotherapy balls or physioballs play an essential role in treating disability or body damages such as neck, waist, knee and so on. Despite their wide range of applications and importance, it is difficult to monitor the damaged member and propose continuous treatment in the presence of a physiotherapist or physician. This causes several problems and costs for the patient. Therefore, a new generation of physiotherapy balls will be created in this project. The idea is to perform exercises and monitoring without the need and/or the presence of a doctor or physiotherapist.

Going On-line with Cognitive Rehabilitation: Testing and Implementing Web-based Goal Management Training at Clinical and Commercial Levels

Goal Management Training® (GMT) is a Baycrest cognitive intervention that has been studied extensively, applied clinically, and manualized into kits for clinicians that have been commercially available since 2012. GMT targets executive functions, a collection of higher-level abilities involved in planning, organization, strategy, and inhibition. Executive impairment can be seen in normal aging as well as in numerous neurological conditions, including dementia and traumatic brain injury (TBI). GMT is the gold-standard treatment for executive impairment worldwide.

Fractal-element based Magnetic Resonance Imaging Coils for Multi-nuclear Imaging

An MRI (Magnetic Resonance Imaging) scanner is a machine that uses magnets and radio waves to take pictures of the inside the human body without needing to use surgery. An MRI scanner is used to look at things like the brain, liver, heart, and other organs in your body. The scanner uses a “coil” placed near the body to take a picture of that area of the body. This research project uses new shapes of coils to better detect the organs hidden inside. The new shapes of coils can also help detect

Application of Brain 23Na "Big Data" for Future Disease Classification

Sodium is a chemical ion which is essential for a healthy brain. The body naturally regulates its concentration inside and outside of cells through normal metabolism. Disruptions in this intricate balance can be caused by various neurological disorders, such as multiple sclerosis, concussion, or Alzheimer's disease. In order to provide personalized medical care, a "big-data" approach is required whereby an individual's brain can be compared to a standardized template or atlas; unfortunately, a sodium atlas, representing normal sodium concentrations, is not currently available.

Improving 23Na – Magnetic Resonance Spectroscopic Imaging through RF Coil Development

Magnetic Resonance Imaging (MRI) machines use radiowaves and large magnets to safely produce pictures from the insides of the body. The radiowaves are emitted and detected by special antennas that surround the body. Most MRI scanning involves measuring of water in the body. But other atoms, like sodium, can also be seen too. This work described here involves designing new antennas to safely see sodium inside the body. More specifically these antennas will be designed based on novel geometric fractal shapes, which are regularly seen with cell phones.

Computer Lenses and Sex Influence on Shoulder-Neck Discomfort and Musculoskeletal Mechanisms in University Students Identifying as Laptop Users

Adults exposed to screens for prolonged periods of time have complained of shoulder-neck discomfort. Ergonomic solutions can help prevent the development of computer work-related pains later on in life as young adults move on to careers in an office or administrative setting. Many computer users have also expressed eye strain. As a response, ergonomic computer lenses have been brought forward, said to make viewing a computer screen easier on the eyes.

The design and fabrication of a novel and passive hand tremor attenuator

Parkinson’s disease is most highly recognized by tremors of the hands that occur in those afflicted with the disease. Though the symptoms of Parkinson’s disease involving motor function begin with very slight tremors of the hands, they further develop into issues such as difficulty swallowing, severe postural problems and extremely limited mobility. In this proposal, a method of reducing these tremors that appear during the early stages of the disease is developed by creating a wearable passive device that reduces vibrations of the hand and arm through the use of magnetic actuators.

Evaluating dining improvements in Schlegel Villages

This project is focused on evaluating dining improvements being implemented by the partner organization, Schlegel Villages (SV). The first study involves one SV where the CHOICE+ Program is currently being piloted. CHOICE+ is a team-based approach to making physical and psychosocial improvement. The team is guided by Champions to make these changes over time; changes include small physical improvements (e.g. music), as well as education and training to support relationship-centred principles for dining.

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