Development of a SEMA3C targeted therapeutic for treatment of clear cell renal cell carcinoma, lung cancer, breast cancer and colorectal cancer

The major focus of this proposal is to perform preclinical studies to support clinical development of a novel inhibitor for treatment of different caners such as breast, lung, colorectal and kidney. We have recently developed a novel therapeutic protein that selectively inhibits multiple pathways for treatment of advanced prostate cancer.

Development of a novel stem cell-seeded extracellular matrix for treatment of chronic wounds

The bedsore or pressure ulcer is a serious health problem that affects many individuals with spinal cord injury (SCI). These ulcers mostly develop on skin that covers bony prominences of the body, such as the hips and tailbone. Pressure ulcers are often very difficult to treat and not only negatively affect patients’ health, but also have profound impact on their quality of life. This speaks to the need for finding more effective treatment methods to address this problem. Our aim in this research project is to find a novel method to improve the healing of pressure ulcers.

A Pilot Clinical Study of Treating Pressure Ulcers in patients with Spinal Cord Injury

Pressure ulcers are among the top five leading causes of re-hospitalization in patients with spinal cord injuries (SCI). Unfortunately, current conventional prevention and treatment methods have neither decreased the prevalence of these ulcers nor significantly improved their outcomes. To address this difficulty, here, we will test the efficacy of our new liquid skin substitute to fill up the non-healing wounds where the skin solidified and promotes the healing process. Our plan in a pilot study is to treat 12 patients who pressure non-healing wounds did not heal in the previous 3 months.

Qualitative Data Collection for Development of an Electronic Application to Promote Home-Based Self-Care in Older Heart Failure Patients: Patient and Informal Caregiver Perspectives

Heart failure (HF) is one of the leading causes of hospitalization and rehospitalization in older adults, yet the majority of HF-related readmissions are preventable if patients can manage their treatment at home. One method to help patients who require extra assistance in following their treatment is through mHealth applications. However, these applications are not usable for many older patients due to their complicated design.

Evaluating a Single-Site Supportive Housing Program for People with Serious Mental Illness and Histories of Homelessness

This project will involve an evaluation of a program to house people who have serious mental illness, and who have had experiences of homelessness. There will be two parts to this study. First, the study will examine how this program has been implemented. A study of the implementation of the program will provide information that the program can use to improve how the program functions. Second, the study will examine the outcomes for people who are housed through the program. A key outcome to be examined will be whether people who are housed able to keep their housing.

Optimizing Movement in Children Study (OMiCS)

OMiCS represents a broad research initiative exploring the relationship between physical literacy (PL) in children and markers of biological health. The research seeks to expand on the literature surrounding the components of PL: physical competence, confidence, and motivation for being active, and determine whether any of these components can shift objective biomarkers of health (the “omics”).

Exploring the lived experience of survivors: The link between intimate partner violence (IPV) and traumatic brain injury (TBI)

Past research has established that a high percentage of women in violent relationships experience a traumatic brain injury (TBI), with one article estimating approximately 23 million women in the US living with a TBI from intimate partner violence (IPV) (Ivany & Schminkey, 2016). While previous research has focused on establishing the link between IPV and TBI, further research needs to be conducted into the experiences of these women. The present project seeks to do exactly that, through interviewing of 6-8 women from The Cridge Centre for the Family.

Evidence-informed Planning and Evaluation of Community Transitions: Impact on Health and Quality of Life

St.Amant is an organization that offers services to support individuals with developmental disabilities. Many of St.Amant’s services are shifting to provide the most inclusive, supportive, community-based services with the intention of enhancing health, access to healthcare, and quality of life of persons served and that of their families and caregivers. One of the current service changes is transitioning 75 individuals from River Road Place (RRP) to a variety of community-based residences.

Evaluation of targeted alpha-therapy on patient-derived Glioblastoma cells

Glioblastoma multiforme (GBM) is the deadliest form of human brain tumors, systematically recurring despite multimodal treatment. As a consequence, the average patient survival is less than 15 months, and is thought to be linked with the presence of brain tumor stem cells (BTSCs) that are implicated in treatment resistance. GBM BTSCs are radiotherapy and chemotherapy resistant, and BTSCs escaping treatment may explain tumor relapse. In the current era of precision medicine, targeted radiotherapy constitutes an attractive strategy for treating intractable disease.

CyTOF-based characterization and isolation of MDSC subsets

Myeloid-derived suppressor cells (MDSC) are an unusual type of blood cell that is able to potently turn off immune responses. These cells are not normally present in healthy individuals, when a tumour is present, MDSC can block clearance of the tumour by the body’s immune defenses. A better understanding of how MDSC shut down tumour clearance would greatly improve the success of cancer treatments. Unfortunately, MDSC are difficult for scientists to study because there is currently no effective method to isolate them in pure form.

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