Statistical and Ethical Implications of Pimavanserin Drug Trials Published with Unexplained or Missing Datasets on Parkinson’s Disease

This project looks to examine the safety of the medication Pimavanserin, marketed under the brand name Nuplazid. Pimavanserin is prescribed to manage Parkinson’s Disease Psychosis, a common side effect of Parkinson Disease medications. This medication has already received regulatory approval in the United Stated by the Food and Drug Administration under a special program called the “Breakthrough therapy program”. Although it initially showed promising results, concerns have been raised regarding its safety and efficacy.

History of the Indian Peoples’ Association in North America (IPANA)

This project seeks to chronicle an alternative history of a cosmopolitan diasporic community of South Asians by foregrounding inter-community organizing by the Indian Peoples Association in North America (IPANA) in anti-racism and labour rights struggles in the 1970s and the 1980s. It is a history erased from the repertoire of conventional diaspora studies, which tends to imagine a community through such concepts as an exclusive ethnoreligious community and homeland nationalism. Dr. Hari Sharma, in whose memory the Dr.

Improving gender equity in sport participation and experiences: Identifying trends and implementing evaluable resources

Canadian girls and women experience disadvantages in sport participation and quality experiences. These challenges have been intensified by the COVID-19 pandemic due to decreases in sport opportunities that disfavor girls and women. Canadian Women & Sport (the partner organization) are committed to improving gender equity in sport and have recently conducted a large survey measuring Canadian youth sport participation and experiences. The current project will implement the survey at the beginning of the first and third years.

Developing MRI Biomarkers for the Differential Diagnosis of Parkinson's Disease

Parkinson's disease (PD) is a neurodegenerative disorder associated with death of dopamine-producing neurons. This results in structural changes to the striatum, substantial nigra (SNc), and ventral tegmental area (VTA). Motor symptoms of PD are extremely heterogeneous causing a high rate of misdiagnosis of similar disorders (e.g. Essential tremor; ET) as PD. This study aims to identify objective indicators of PD with MRI, to help physicians differentiate PD patients from healthy people, and ET patients. 60 participants from each group will be recruited.

OPERA – Optimization of Predictive Electrocardiographic Risk Analysis

Sudden cardiac death (SCD) is a leading cause of mortality in Canada and globally, accounting for nearly half of all cardiac deaths. Alterations in beat structure (morphology), caused by the heart’s electrical system and autonomic nervous system, and the left ventricle ejection fraction are significant risk markers proposed to identify those at risk of SCD. Historically neither alone have provided sufficient accuracy in predicting SCD.

Supporting adolescent athletes through a team building and mental health program - Year two

Canadian adolescent athletes suffer many mental health challenges such as hyper competitiveness and a culture of silence which often precludes individuals from discussing mental health issues. These challenges have been compounded by the COVID-19 pandemic. Team Unbreakable (the partner organization) have run a highly successful physical activity and mental health program which is implemented through local school boards. The current project will adapt this program by integrating a team building module which will be implemented through coaches of community sport programs.

Engaging young people and fostering intergenerational collaboration: Assessing the impact of initiatives within the nature conservation sector - Year two

The International Union for the Conservation of Nature (IUCN) has served as a global authority on sustainable development and environmental governance for over seventy years. Responding to broader trends within these areas, the IUCN has sought to foster engagement with young people as a strategic priority-to move beyond tokenistic involvement toward institution-wide intergenerational collaboration. The Canadian Committee for the IUCN (CC-IUCN) has been particularly dedicated to this work.

Development of Fully Compostable Beverage Cups

The objectives of the proposed research are to develop fully compostable and biodegradable beverage cups in Manitoba, using paper made from “waste” biomass (canola straw, cattail biomass) biodegradable polymers.

Reducing homelessness using direct cash transfers (expansion project)

The goal of this project is to examine the effect of one-time unconditional direct cash-transfer to recently homeless individuals in Vancouver, BC, Canada. Building on promising results from our research team’s ground-breaking pilot randomized controlled trial (RCT) with 50 cash recipients, the current project seeks to confirm this preliminary evidence using a larger RCT with 200 cash recipients. To evaluate the impact of the cash transfers over time, participants will complete surveys before receiving the cash, and 1, 2, 3, 6, 9, and 12 months after the cash transfer.

Facilitating the recycling process of catalytic converters using computer vision

Catalytic converters used in car exhausts are effective means of reducing pollutant emissions from internal combustion engines under normal operating conditions. They contain precious metals which makes them attractive for recycling due to their metal value and also the sustainability of the demand for these metals. The price of Catalytic converters can be determined based on their models and the amount of metal that exist in them.