Data Mining in the VISTA Clinical Trials Database

The project aims to apply data mining in the VISTA clinical trails database at the Geriatric Medicine Research Unit. The data contains information about Alzheimer’s disease (AD) patients, some of whom received cholinergic treatment and some of whom did not receive this treatment. Because of the variability of responses to treatment as well as the variability in the course of disease progression, it is difficult to identify the patterns robustly associated with improvement, which is crucial in justifying the choice of treatment.

Metric Development to Interpret Measures of Medication Compliance

Medication non-compliance is associated with poor outcomes in patients. Although different methods are currently used to measure compliance, the ability to translate this measure into a meaningful metric, which is interpretable for both methodologists and clinicians, has not yet been realized. Medication compliance has become an increasingly important area of research as policy makers perceive the extent and effect of the problem that non-compliance poses.

Mathematical Modeling in Pharmaceutical Development

Microtubules are a key constituent of the cell's structural framework and are responsible for a diverse range of functions within the cell. They are cylindrical polymers, 25 nm in diameter and can grow to be several hundred micrometers in length. Tubulin, the protein which is the main component of microtubules, self-assembles to form the walls of the cylinder in a highly-ordered, helical lattice arrangement. Functionally, microtubules fill a wide variety of roles within the cell. The function often considered most important is the role played in cell division.