Trusted Records in TAPESTRY Approach

New America's Future of Property Rights program aims to create a solution for people all over the world to achieve their basic human right "to own, rent, or otherwise occupy property" (Panfil & Mellon, 2019). What is denying a large part of populations their basic human right is the "lack of proper documents" (Panfil & Mellon, 2019).

Determining the antidepressant effect of 2-bromo-LSD (TD-0148A)

We would like to determine whether a modified version of LSD (TD-0148A), which does not induce hallucinations, has antidepressant effects that can be applied to patients with depressive disorders. We will investigate whether TD-0148A can change the physical structure of neurons, as other antidepressants do. Furthermore, we will use an animal model to determine whether TD-0148A can reverse the negative effects of chronic stress, whish is a leading cause of depression in people.

Positive pombe: engineering anti-depressant molecules in fission yeast

The COVID-19 pandemic has increased depression and anxiety in Canada, adding to the current opioid drug dependency crisis. Mental health supports can be used with drug options to relieve symptoms and promote better health. Some cases of depression are resistant to treatment, and alternatives are needed that bring patients relief. Psilocybin is a compound found in “magic mushrooms”. Psilocybin is a highly effective anti-depressant; it is also non-addictive, and less toxic than many medications including caffeine and alcohol.

Developing A Drug-Protein Interactome for Identifying Potential Drug Targets In-situ

Our method reveals the interaction landscape of a given drug. We will generate a two-part biosensor inside living cells. The first part involves a genetically encoded reactive ‘beacon’. The second part is the drug of interest, synthetically modified with complementary reactivity to the beacon. When present together in cells, both parts chemically combine to form a chimeric ‘drug-beacon’, which will then report on the local protein environment of the derivatized drug by using proteomics.

S’oh Sin geez (Breathing Properly): Optimizing COPD Virtual Care in First Nations Communities

COPD is a lung disease characterized by shortness of breath, reduced activity tolerance, and poor quality of life. First Nations people have a high prevalence of this condition. People with COPD are encouraged to take an active role in managing their health, but this is challenging for people living in remote or rural locations. To improve disease management and access to care, many First Nations communities have turned to telehealth systems. However, many systems are primarily video-conferencing systems to enable live conversations between patient and practitioner.

Flow control and efficiency: Improvement of fluid-driven actuators to build soft gloves for rehabilitation

The current project aims at designing a soft-robotic wearable glove which is applicable for rehabilitation of patients with loss of motor function in one or both hands. The wearable glove takes advantage of a set of different fluid-driven actuators. In order to design the actuators, flow control technique and also combine a set of actuators to use in the wearable glove, it is required to precisely analyze the fluid-solid interaction (FSI) between the actuator flexible body and the driving fluid.

Opportunities for Sino-Canadian Collaboration in Global Health Governance and Multilateral Pandemic Response

The coronavirus pandemic has elevated global health governance from a “low politics” position in foreign policy practice to an economic and security priority of international importance. Conventional foreign policy approaches to pandemic management have proven ineffective in the time of Covid-19, as states struggle to fulfil public health obligations in an increasingly globalized world. Canada’s inability to contain and manage the coronavirus is further complicated by its challenge of navigating a global order shifting to multipolarity as a middle power with close ties to the United States.

Developing computation tools for the rational design of cyclic peptide therapeutics

The majority of drugs that enter the market are discovered by screening millions of random chemical compounds until a desired effect is achieved. With the recent explosion in available biological data and raw computing power, it is now possible to develop drugs through bottom-up design rather than trial-and-error testing. Bottom-up drug design has the potential to lower R&D costs, improve success rates and reduce therapeutic side effects. ProteinQure aims to achieve these goals by designing peptide therapeutics computationally.

Network and Data Security Access Control

Imagine a refrigerator automatically orders the eggs from the online store to deliver at its location and make the payment on behalf of the owner. In today’s world, the network infrastructures are not limited to traditional datacenters or company’s premises. IoT (Internet of Things) and BYOD (Bring Your Own Device) are growing rapidly in our life. Network and Data Security Access Control plays a vital role to protect our data from being stolen intentionally or unintentionally.

Automation & Orchestration for Improved Security Communication

Speed is incredibly important when addressing issues with computer security. The longer the time between the attack’s start and resolution, the more assets that attackers can steal from a company. There are various security platforms that can alert a company to a cyber-attack. This research project aims to combine knowledge from all these platforms together at faster speeds than a human would be able to do. The cooperation between security platforms will allow ISA Cybersecurity Inc. to detect and respond to cyber-attacks faster than previously possible.

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