Our focus in this computational proposal is on weak bonding interactions (WBIs) in the organization of molecular assemblies, here in particular oligonucleotides. With regards to WBIs, the hydrogen bond is certainly the most recognized, but C-H...O, C-H...pi, pi...pi and others must not be ignored if organization and stability are to be understood. WBIs are thus of fundamental importance in diverse phenomena, such as the effect of ligand-binding in ribonucleic acids on gene expression (riboswitches, mostly through pi...pi interactions).