Evaluation of Signal Mass as a new marker of brain tissue loss in multiple sclerosis

The degree of brain cell injury and death may be associated with disability and problems with memory and thinking skills in patients with multiple sclerosis (MS). This is most frequently measured by using magnetic resonance imaging (MRI) images to calculate shrinkage of brain volume. In fact, MS patients suffer more rapid shrinkage of brain volume compared to healthy people. However, brain volume can also fluctuate due to reasons other than brain cell death, such as water coming in and out of the brain.

Ultra-low power wireless sensor node design for health monitoring use cases

In this project we address the problem of power consumption for wireless sensor nodes. This is where among different components of a sensor, RF transceivers consume a significant amount of power e.g. approximately 80%. Hence the main objective is this project is to tackle the power consumption problem at the RF transmitter, where we aim to reduce the power consumption to micro-watts of power, with minimal sacrifice in achievable data rate and by keeping the connectivity range within an acceptable radius.

Expression of muscarinic receptors in neurogenic detrusor overactive (NDO) bladders of spinal cord transected (SCT) rats after preventive treatment with anticholinergic me

Following the study of spinal cord transected (SCT) rat models being treated by fesoterodine fumarate (antimuscarinic drug) to prevent neurogenic detrusor overactivity, bladders of all 30 animals were conserved. It was observed that an early fesoterodine fumarate administration at the time of transection modulates bladder overactivity. However, the exact mechanism of action is not known and should be investigated further focusing on detrusor muscarinic receptor modifications in order to support clinical trials with humans.

Evaluation of probiotic bacterial strains for enhanced microbial biotransformation of polyphenol-rich potato extract

The proposed project searches to understand the effect of probiotic bacterial strains belonging to the Lactobacillus and Bifidobacterium genera on the degradation and bioavailability of phenolic compounds present in potatoes (Solanum tuberosum L.) after in vitro digestion. The more easily absorbed metabolites are associated with protective effects against cancer and diabetes mellitus type II. Additionally, the combination of probiotics with phenolic-rich potato extract may have beneficial effects on the human colonic bacterial composition.

Bioactive peptides and joint inflammatory response after in vitro human digestion of collagen hydrolysate

Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol® Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following digestion, hydrolyzed collagen yields amino acids and peptides that can lead to the health promoting properties of the supplement. However, the specific identity and mechanisms of action of the peptide and amino acids produced from the digestion of the Genacol collagen hydrolysate that support joint health is unclear.

Understanding the cellular mechanisms sustaining functional capacity improvement with prehabilitation in colorectal cancer patients

Cancer is associated with weight loss, decreased muscle strength and inflammation. This has a tremendous impact on daily activity, autonomy and quality of life, involving both patients and care-givers. I previously worked on a preoperative intervention called ‘pre-habilitation’, a personalized exercise and nutritional supplementation delivered before surgery. The main idea is to prevent postoperative complications utilizing the time before surgery to put the patient in a better physical, nutritional and emotional state.

Machine Learning for the Telecommunication Industry

Ericsson is an industry leader in offering telecommunication solutions and products. As an important step on the path towards the automatic and autonomous management of next generation networks, Ericsson is developing technology in machine learning and artificial intelligence that will benefit operators around the world, including in Canada where Ericsson supplies technology to most of the major telecommunication network operators.

Using multivariate deep-learning algorithms for automatic quality control of high-resolution MRI - Year two

NeuroRx is an imaging contract research organization (CRO) specialized in the central nervous system (CNS) that utilizes state-of-the-art digital image processing techniques to produce accurate and precise outcome measures for clinical trials of drugs in development. Prior to analysis, all scans must pass Quality Control (QC). The goal of this project will be to incorporate advanced computer algorithms to automatically classify the quality of high-resolution structural brain Magnetic Resonance Images. The advanced computer algorithms will include deep learning algorithms.

Efficacy of the plant extract CELEXT07 and the botanically derived Thymox in suppression of Cannabis fungal diseases under greenhouse production systems

The legalization of Cannabis (marijuana) is now supported by 66% of Canadian voters. Aphria Inc., was the first approved and licensed producer under the MMPR to begin growing in a greenhouse and is currently the second-largest marijuana producer in Canada. Unfortunately, Cannabis is attacked by a plethora of phytopathogens leading to a number of diseases with the most commonly reported are grey mold and powdery mildews.

Probiotics and their role in an intestinal inflammation: Use of a novel in-vitro model to understand mechanisms of action

In recent years, there has been a growing interest in the role the gut plays in our overall health and wellbeing. Changes to this gut microbial population has been linked a host of disorders, ranging from metabolic disorders such as diabetes and obesity to mental disorders such as depression and anxiety. Depending on lifestyle factors, diet, antibiotic use and age, certain populations can be at a greater risk of microbial imbalances. In order against such conditions, probiotics are used as therapeutic agents.