Magnetometry with spin-based sensors

The summer intern will participate in a project aimed at using single defect centers in diamond to map out the magnetic fields generated by driven ferromagnetic circuits. Nanoscale magnetic circuits are critically important to computer hardware, especially in applications that use ferromagnetic domains to encode information. For example, magnetic random access memory (MRAM) could potentially replace standard DRAM while drastically reducing the demands for power.

Hydrogen trapping at nanoscale alloy carbides in high-strength steels

Hydrogen, when dissolved in metal or alloy lattice, can render the otherwise ductile material brittle. This phenomenon, namely hydrogen embrittlement (HE), has been a persistent obstacle for the application and development of high strength steels. One effective means to enhance the high strength steel’s resistance to HE is to introduce nanoscale alloy carbides (NACs) into the microstructure, evidenced by the increased emission temperature of hydrogen and delayed fracture under the same hydrogen charging condition. The role of NACs in HE is often attributed to them trapping hydrogen.

Statistical challenges in individual patient data meta analysis

In a typical meta analysis, estimates of the parameter of interest (e.g. odds ratio) are extracted from the literature or by contacting researchers and pooled together. In contrast, for IPD-MA line-by-line patient data are obtained from each study.
IPD-MA data permit researchers to define exposures and outcomes consistently across studies, and to analyze the association of interest consistently (e.g. adjusting for the same confounders), which may minimize heterogeneity. IPD-MA are of particular value for synthesis of observational studies.

Regulating Innovation: Law and the Creative District

We will investigate the relationship between law and innovation in our newly globalized era. We will draw on well-documented innovative districts in Montreal and Silicon Valley to assess how law promotes or hinders such innovation. We will consider emerging initiatives such as the Blueseed startup community, which is a proposed un-regulated innovation zone to be located in international waters in order to avoid national regulatory compliance regimes.

Developing new viscoelastic substrates for cell mechanics studies

Traction force microscopy is a well-established methodology to measure the local contractile forces exerted by a cell, and is accomplished by measuring the deformation of a soft elastic substrate by cell forces. From this measured deformation, the strain is calculated, and by knowing the elastic modulus of the substrate, the forces are calculated. Key changes in physiology and pathology are reflected in these cell forces, such as in metastatic progression of cancer.

Energy-efficient thermal management in deep underground mines

It is well known that underground miners are exposed to one of the most dangerous working environments on earth. As miners delve deeper into the earth, the rock pressure and temperature rise, which in turn have an adverse effect on the environment and thus lead to higher operating costs. Furthermore, in coal mines where methane gas and dust is also produced in coal beds, the combination of methane accumulation, oxygen and spark/heat can trigger explosions – which may cause fatal accidents. Generally, mining environments are dynamic and changing very rapidly during extraction process.

Perioperative use of opioids and risk of ovarian cancer recurrence and metastasis

Objective. The primary objective of this cohort study is to determine if use of opioids increases the risk of ovarian cancer recurrence and metastasis.

Design and Synthesis of Covalent Enzyme Inhibitors

Introduction. Fibroblast activation protein-? (FAP), an enzyme of the S9 protein family, was identified as a major player in the activation of the stroma required for tumor growth and proliferation and progression of cancer cells. In parallel, prolyl oligopeptidase (POP), an enzyme of the same family, has been found to be responsible for the production of a potent stimulator of angiogenesis and that its inhibition arrests the growth of cancer cells.

Enhanced Remote Viewing Capabilities from a Camera Array

The project will entail one or more of the following activities, depending in part by which elements are completed in the summer of 2014.

- adding "last mile support" for rendering 3D stereoscopic display from the dual-interpolated views we're able to generate
- implementing a dynamic camera-swapping selection mechanism based on the current set of requested viewpoints to achieve maximum quality and smoothness as users move between views
- evaluating the limits of scalability of competing rendering architectures, in which interpolation is carried out client-side rather than server-side

Structural Investigation of an antibiotic-producing NRPS

Pacidamycins are group of peptide antibiotics which act against the Pseudomonas human pathogens by inhibiting cell wall biosynthesis. Pacidamycins are produced in Streptomyces coeruleorubidus by proteins of a nonribosomal peptide synthetase (NRPS) gene cluster. NRPS are a class of modular proteins that synthesize small peptide products with a wide variety of chemical and biological properties.