Printable/sprayable anti-infective and anti-fouling coatings based on biomedical-grade polymers

Despite substantial research efforts, the problems of spreading infectious diseases (such as COVID-19) through surface transmission and infections associated with medical devices persist. One promising solution is to apply a coating to the surface of concern that can provide effective surface disinfection. However, existing approaches typically provide only short-term disinfection effects (a few hours), contain materials having potential human or environmental health risks, or require specific fabrication steps that can be performed only during device manufacturing.

Development of the McMaster Cough Monitor (MaCough)

Chronic cough is a persistent daily cough that lasts greater than eight weeks and affects 10% of the general population. It is associated with a significant burden on health and quality of life. In clinical practice, there are very limited tools in order to quantitively monitor cough. Existing products are too expensive and labor intensive, making it impractical for use in day-to-day clinical practice. This project is aimed to create a quantitative way for clinicians to be able to diagnose, assess and monitor cough more efficiently.

A combination host-pathogen rapid diagnostic technology for decentralized monitoring of respiratory infections

Current testing for SARS-CoV-2 focuses on detection of the pathogen via isolated nucleic acids, routinely from nasopharyngeal swabs. To our knowledge, no approved clinical SARS-CoV-2 diagnostic tests using nasopharyngeal swabs incorporate measurements of host responses at the time of diagnosis. Monitoring host responses during SARS-CoV-2 infection is important, as stratification of COVID-19 patients based on host responses is predictive of mortality.

Metabolic Targeting of Inflammatory Pathways for the Treatment of Non-Alcoholic Steatohepatitis (NASH) and Chronic Kidney Disease (CKD)

Non-alcoholic steatohepatitis (NASH) and/or chronic kidney disease (CKD) affect more than 5 million Canadians. Progression of CKD is the primary cause of end-stage renal disease while NASH is now the leading cause of liver cirrhosis and liver transplant.

A low-cost wearable tele-health monitoring system for chronic and infectious diseases

Continuous monitoring of health allows for early diagnosis and tracking of disease progression, thus enabling timely medical intervention. However, continuous monitoring of the patients' health is conventionally conducted in hospitals or long-term care facilities with expensive, bulky, and unobtrusive systems, which require skilled professionals to operate.

Development of Nanostructures Embedded Early-Warning Electronic Sensing Device for Roadside Ultra Low Level Detection of Cannabis, cocaine, opiates, and Alcohol in Saliva

Drug-impaired driving represents a significant and increasing threat to the safety of Canadians and there is an urgent need for a convenient, instantaneous and accurate road-side evaluation technology for impaired driving. Current solution for roadside drug testing includes a device that is still just a qualitative indicator. Quantitative detection of drugs currently require expensive equipment, dedicated infrastructure and specialized laboratory personnel. To address this problem, eye3concepts inc.

Toward the development of a framework for research collaboration between public libraries and universities

Public libraries and universities can benefit greatly by partnering to conduct research. To ensure the sustainability and impact of these partnerships, they need to be grounded in an awareness of each organizations’ research needs, goals, resources, and strengths. This project will produce a framework that guides public libraries in identifying research needs, strategically selecting university partners, and developing research plans that address each organizations’ roles and responsibilities.

Robust Non-contact RF Sensing for Human Vital Sign and Activity Monitoring

Non-contact sensing for vital signs and human activities utilizing wireless signals has attracted a lot of attention in the last few years. Sensing using Ultra-wide-band or milli-meter wave radios is advantageous in its ability to penetrate garments or walls, operate under different lighting and weather conditions, and better preserve people’s privacy. Despite successful research demonstrations, there remain significant gaps in practical adoption and deployment. Many challenges need to be addressed to handle the presence of multiple subjects, subject diversity and environmental interferences.

A novel intraocular injectable platform for long-term treatment of retinal diseases.

Retinal diseases are the leading causes of blindness in Canada. Retinal diseases are currently treated by monthly or bimonthly intraocular injections of biologics. At the Sheardown lab, we are developing a new injectable hydrogel that can provide prolonged treatment for retinal diseases. Upon injection, the new treatment forms a transparent solid depot inside the eye that doesn’t interfere with the patient’s vision. The depot provides sustained release of the biologics over several months and is completely resorbable after delivery of its payload.

Dynamic, real time quality optimization of streamed video

Twitch is a video live streaming service and a subsidiary of Amazon. Twitch primarily focuses on video game live streaming, broadcasts of esports competitions, music and creative content. Twitch clients upload their encoded video to Twitch’s servers. The user generated content (UGC) is then transcoded. Transcoding is the process of decoding UGC, making alternations to it, and then encoding it again. During transcoding, video will be encoded at a lower bit rate or its resolution might be lowered.

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