Impacts of once-through cooling on the aquatic environment

Many thermal power plants, including Bruce Power, rely on once-through cooling using water from the Great Lakes. The warmer water that is released back into the lake has the potential to impact temperature sensitive aquatic species that occupy the near shore water close to the discharges. The proposed research will investigate the genetic population structure of three fish species surrounding Bruce Power (lake whitefish, round whitefish, yellow perch), and study the impacts of varying water temperature on embryonic development and post-hatch fitness.

Investigating optimal surface functionalization strategies for linking NanoPhyll coatings to PVC

Environmental pollution is one of the greatest problems that the world is facing today. The conventional detergent and surfactant water based methods are costly, not eco- friendly. Applying photocatalytic coatings that utilize solar energy on the exterior and interior surfaces of buildings is a promising method to tackle air pollution and clean the surfaces with lower cost. Upon sun light and ambient light, after a few chemical reaction, TiO2 nano-particles as a photocatalyst generate reactive agent, which can oxidize organic substances.

Selective Spray Oxidation of Impurity Metals

This research project seeks to develop a novel method for selectively oxidizing impurities in metals. Using available plasma spray technologies, this project will determine a set of parameters to optimize the effect of oxidation in certain metal samples. Three sample metals to be tested are German silver, Sterling silver, and 18 Karat gold. The goal will be to target the oxidation of impurities present in these metals such as nickel and copper.

Comparative effectiveness of prophylactic therapies for necrotizing enterocolitis in preterm infants: a network meta-analysis of randomized trials – Phase II

Necrotizing enterocolitis (NEC) is the most common and serious intestinal disease among premature infants. It happens when tissue in the small or large intestine is injured or begins to die off. This causes the intestine to become inflamed or, in rare cases, develop perforation. It is associated with significant mortality and morbidity in preterm neonates. Current literature on prevention of NEC lacks direct and indirect comparisons of available therapies. Using state-of-art methods (e.g.

Large-scale production and photostabilization of microparticle and nanoparticle-based delivery vehicles for plant immune aids

New approaches are required to secure our food supply in response to the growing world population, rapid diversification of pests, and accelerating weather-related impacts of climate change. Suncor has recently developed a new category of plant immune aids that activate a plant?s native immune system to induce a range of beneficial responses, including greater resistance to both pest-based and weather-based environmental stresses, while avoiding some of the downstream challenges associated with existing pesticide and fertilizer use. Through this collaboration with Dr.

Qualitative Data Collection for Development of an Electronic Application to Promote Home-Based Self-Care in Older Heart Failure Patients: Patient and Informal Caregiver Perspectives

Heart failure (HF) is one of the leading causes of hospitalization and rehospitalization in older adults, yet the majority of HF-related readmissions are preventable if patients can manage their treatment at home. One method to help patients who require extra assistance in following their treatment is through mHealth applications. However, these applications are not usable for many older patients due to their complicated design.

Budget Impact Analysis guidelines for submissions to provincial drug plans in Canada (Update 2018- 2019)

In the health technology assessment (HTA) process, cost- effectiveness analysis gets more attention, however over last decade, the budget impact analysis (BIA) has certainly become more important to the subsequent steps, including the adoption decision. The first Canadian BIA Guidelines was published by Patented Medicine Prices Review Board (PMPRB) in 2007. According to the results of a recent survey with regards to validate the practicality of the guidelines for policy makers, an update was recommended in order to reflect the changes that have occurred in the pharmaceutical industry.

Evaluation of targeted alpha-therapy on patient-derived Glioblastoma cells

Glioblastoma multiforme (GBM) is the deadliest form of human brain tumors, systematically recurring despite multimodal treatment. As a consequence, the average patient survival is less than 15 months, and is thought to be linked with the presence of brain tumor stem cells (BTSCs) that are implicated in treatment resistance. GBM BTSCs are radiotherapy and chemotherapy resistant, and BTSCs escaping treatment may explain tumor relapse. In the current era of precision medicine, targeted radiotherapy constitutes an attractive strategy for treating intractable disease.

Improving Cellulose NanocrystalPerformance through Understanding of Thermal and Colloidal Stability

Cellulose nanocrystals (CNCs) are natural bio-based nanoparticles that can be used to modify the viscosity and improve the performance of various fluids. For this reason, they are of interest to the oil and gas industry, where they can replace other expensive and non-biodegradable polymers that are commonly used. CNCs must first be modified so that they do not degrade or settle at high temperatures and pressures. To accomplish this, CNCs will be extracted from cotton using a variety of methods or by post-modifying the nanoparticle surface to have new chemical groups and new functionality.

Portfolio Strategies under Scenario Optimization

This project concentrates on the scenario optimization method which does not need to make any assumption for the underlying asset distribution and directly incorporate such uncertainty into the objective or constraint functions through stochastic programming. The scenario optimization is performed under different parameters and constraints while Markowitz and Black-Litterman model are taken as the benchmarks to evaluate if the scenario optimization can outperform the traditional methods with the same input exchange-traded funds (ETF) data.