On-Chip True Time Delay Optical Beamforming for RF Phased Arrays

Our space-based radio-frequency communication is suffering from the use of simple phase shifters. Its bandwidth capability is limited, ultimately reducing the satellite’s capacity and the system’s service availability. Most electronic beamforming implementations are bulky, frequency dependent and they consume a significant amount of power. To replace those electronic components, structures which guide light on microchips have been suggested and demonstrated to work similarly to how light inside of fiber-optic cables now all brings TV and internet to our homes.

Novel image processing techniques of standard DXA scans to better predict hip fracture risk

Osteoporosis is a generalized skeletal disorder common in older adults, in which a reduction in Bone Mineral Density (BMD) decreases bone’s strength and can result in an increased risk of fragility fractures. One of the sites commonly affected by osteoporosis is the proximal femur (“hip”), the fracture of which greatly decreases mobility and function, as well as being responsible for high health care costs for society (estimated at $619M annually)1,2.

We have developed novel image processing techniques to extract much more information from each clinical DXA scan than simply a BMD measure.

Investigation of IL-5R? expression on ILC2 as a target for Benralizumab

A newly identified group of cells termed type 2 innate lymphoid cells (ILC2s) have been discovered in the past decade. Increasing evidence supports the view that ILC2s play a central role in driving the cellular changes in the airways of asthmatic subjects. ILC2s are increased in severe asthmatics with uncontrolled inflammation despite being on the highest doses of accepted therapies like oral and inhaled steroids. Finding pathways that control ILC2s may provide additional therapies to control severe asthma.

Evaluation of recombinant bovine herpes virus-1 as a platform for novel cancer immunotherapy development

The most recent breakthroughs in cancer treatment are based on understanding that our immune system can be activated to attack tumours. While first achieved using antibody drugs called “checkpoint inhibitors”, this new paradigm of activating a cancer patient’s own immune system is also possible using viruses, an emerging field known as oncolytic virus (OV) therapy. The idea of OV stems from certain viruses that cause minimal disease in humans but have the ability to infect and subsequently elicit an immune response against cancer cells. Dr.

COVID-19 Infection and Epithelial Cell Markers

Covid-19 has emerged as a major health concern in 2020, with a mortality rate of 11%. Covid-19 is due to a new coronavirus, SARS-CoV-2, which enters the human body through a receptor called ACE-2 in the airway. Asthmatics are usually at increased risk for viral infections, which exacerbated their asthma symptoms, however early clinical studies suggest that asthma is not a main risk factor for developing Covid-19, and that asthmatics taking inhaled steroids possibly have less of the ACE-2 receptor in their airways.

Investigations into the mechanism of action and potential in idiopathic pulmonary fibrosis of the novel ruthenium based therapeutic BOLD-100

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease lung disease with unknown cause. There are limited treatment options for IPF and investigations into new treatment options is needed. BOLD-100 is a clinical-stage small molecule that is currently being investigated as a treatment option in oncology and viral infections. The pathway that BOLD-100 impacts, the unfolded protein response, is important in IPF and therefore this project’s objective is to use preclinical models to test whether BOLD-100 can affect development of IPF.

Leveraging linked, person-level health information to inform resident safety and a risk management framework within retirement homes in Ontario, Canada

The retirement home sector in Ontario is rapidly expanding, given the need for assisted living services to support an aging population, coupled with health system issues related to hallway health care and a deficit of long-term care capacity. However, there is no research on this sector to inform policies related to risk assessment, quality of care, and retirement home sector performance.

Numerical and Experimental Investigation of Drive Motor Thermal Performance

This research project is related to the development of innovative solutions to enhance thermal performance of self-contained DM systems. The project will be carried out in collaboration with Van der Graaf Inc. (VDG), which is a Canadian company located in Brampton, Ontario. A long-term plan has been developed by the applicant and the industrial partner. The main objective is to help VDG produce DM systems with superior thermal performance capability and equipped with in situ sensors providing the user with live data about the overall thermal performance of the system.

Developing a rapid point-of-care COVID-19 detection test with the potential to collect and transmit data

The McMaster graduate student will be involved in various aspects of the design and development of a point-of-care COVID-19 diagnostic and data gathering system. The intern will be responsible for preparing and testing saliva samples for the Sars-Cov-2 virus. An innovative colorimetric paper-based test strip will be used to detect the presence or absence of the virus.

A participatory approach to redeveloping coach and volunteer online training modules: A Special Olympics context

"On-going coach and volunteer training are essential to providing high-quality, evidence-informed practices in sport settings. This study aims to extend Special Olympics Ontario and Special Olympics Canada's online training platform for coaches and volunteers by working with athletes with intellectual disabilities, current Special Olympics coaches, and families of Special Olympics athletes.

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