Developing A Drug-Protein Interactome for Identifying Potential Drug Targets In-situ

Our method reveals the interaction landscape of a given drug. We will generate a two-part biosensor inside living cells. The first part involves a genetically encoded reactive ‘beacon’. The second part is the drug of interest, synthetically modified with complementary reactivity to the beacon. When present together in cells, both parts chemically combine to form a chimeric ‘drug-beacon’, which will then report on the local protein environment of the derivatized drug by using proteomics.

Flow control and efficiency: Improvement of fluid-driven actuators to build soft gloves for rehabilitation

The current project aims at designing a soft-robotic wearable glove which is applicable for rehabilitation of patients with loss of motor function in one or both hands. The wearable glove takes advantage of a set of different fluid-driven actuators. In order to design the actuators, flow control technique and also combine a set of actuators to use in the wearable glove, it is required to precisely analyze the fluid-solid interaction (FSI) between the actuator flexible body and the driving fluid.

Cozy Games and Character-Driven Narratives as an Effective Tool for Pediatric Voice Therapy

This project explores the development of new media and technology to aid speech-language pathologists (SLPs) specializing in voice therapy. Existing vocal therapy resources lack effective game interactivity and compelling character-driven narratives, both of which are known to increase motivation and engagement in learning. Clinicians do not have the expertise or know-how to utilize game mechanisms in the media they are developing, nor are they experts in the realm of story, fantasy and experiential learning.

Smart Dashboard for Sustainable Destination Decision Making Part 2

Destinations have quickly become victims of their own success. Destination Management Organisations (DMO’s) worldwide are making a much needed shift towards the inclusion of management alongside their marketing priorities for destination management, but are often ill equipped. There is a current gap in the marketplace for useful, comprehensive and user-friendly tools to assist them.

Pre-arrival services: The missing piece in the immigrant integration puzzle?

Although the education level of immigrants arriving in Canada has been steadily increasing, finding appropriate employment has remained a constant challenge for many newcomers. In an effort to improve some of the barriers that immigrants face, immigrant service organizations (ISOs) have started providing pre-arrival services for immigrants before they set foot in Canada. Pre-arrival services include orientation sessions, language classes and workshops on various topics such as job search strategies and occupational licensing.

Machine Learning for Auto-Scaling Corda Node Containers

We are looking to drive the operational cost down for Corda R3 nodes. Corda R3 is a smart-contract Distributed Ledger technology. Our strategy is to do so by minimizing the cloud computing resources. Using machine learning and historic data we can proactively orchestrate a large number of nodes on behalf of our clients. The interaction between nodes is a type of social network lending itself to machine learning.

Improving glycerol utilization in E.coli for heme biosynthesis

Heme is a naturally occurring molecule found in our blood and as well as in animals, responsible for carrying oxygen throughout our body. Interestingly, heme has been commercially used in various products such as in cosmetics, nutraceuticals, and food. The traditional production of heme however often involves animal slaughter and harsh chemical processing, which is costly and ultimately limits other potential applications. The proposed project will investigate a different method of producing heme by fermenting microorganisms; much in the same way that beer, wine, and insulin are made.

Saccade Concussion Diagnosis System

The underlying technology will leverage artificial intelligence (AI) to analyze oculomotor (eye movement) data to learn and extract human translatable features/symptoms of concussion. The software is computationally light-weight that is capable of running on portable hardware with minimal computational power. The intern will examine the system's commercialization by conducting interviews with potential customers and identifying the additional critical features needed by end-users.

Silicone-mounted fiber-Bragg grating sensor for cardiac pulse-waveform monitoring

Cardiovascular disease (CVD) is a major cause of morbidity and mortality internationally. Current CVD diagnostics are limited to basic tools that provide a generalized number without quantitative indication of overall health, such as blood pressure, or lifestyle risk scores. More invasive diagnostic imaging can be done, but at great cost to the healthcare system. We have developed a basic optical device capable of non-invasively studying the cardiac pulse-waveform, thus potentially allowing for direct measures of cardiovascular risk and health.

Accelerated Maturation of Rye Spirits

Whisky is made by a process of fermentation, distillation, and maturation. The last step is by far the most time-consuming part of this process. In order for maturation to occur, the distilled spirit must sit in a wooden barrel for years, during which the spirit takes on the familiar colour and taste of whisky. This inefficient process is an antiquated approach to creating this beloved class of beverage.

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