Prostate cancer is the disease of the old, effecting 1 in 7 Canadians with a death burden of 1 in 28. The management of the disease becomes extremely difficult with the development of the nonresponsive and aggressive form of the cancer. Thus, the clinicians are rendered helpless and hence there is an urgent need for the development of new targeted therapies. Response to chemotherapy drugs varies for every individual, leading to adverse effects in many. Hence every individual responds to chemotherapy drugs differentially, matching the right dose for individual patient is a big challenge.
The issue has attracted researchers from multiple disciplines, including Danielle Benesch, who is examining how perceptions of free will could impact our response to the overdose crisis. Danielle, a Mitacs intern from the Universität Osnabrück in Germany, has studied free will and decision-making for years. She travelled to Canada this summer to work on a project, supervised by Professor Eric Racine of the Université de Montréal, to research the relationship between perceptions of free will and addiction.
The procurement process of an organization is key to understand company costs. Organizations gather large amounts of data coming from different sources (e.g. income statement, balance sheet, general ledger lines). This information is heterogeneous in nature as it is a mix of unstructured and structured data. Moreover, it needs to be cleaned and consolidated in a taxonomy to enable category management. The objective is to group like-to-like items and/or services into categories from Supply Market Analysis point of view and consider category management for the holistic spend.
Given a set of financial instruments with inherent characteristics at different time intervals, we are interested in finding an optimal trading rule in a high-frequency trading context. A trading rule is defined as a combination of indicators as well as an entry threshold (and potentially other trading parameters). The objective function we are trying to maximize is the profits of the strategy based on the trading rule. One impact of the non-linearity of such problems is that the gradient of the objective function is hard to estimate using a black-box approach.
The ability to impede/reduce complication of the damaged heart presents a major challenge in the treatment of cardiovascular diseases. Complications include heart failure, which has a high mortality even with current treatments. The use of a new drug to stimulate protection of the heart during an ongoing myocardial infarct and long term changes leading to heart failure would be very relevant to the clinical setting, to help patients suffering from diverse heart problems.
This project aims at evaluating whether recent results in deep learning models, trained to exploit weak labels (Hwang, 2016) can serve to extract meaningful lesion localizations from image-level labels, either from individual scans or given a (longitudinal) sequence thereof. To this end, we will scale up existing models that have been shown to work on 2D images to a 3D context, studying labeling performance as the dataset size grows.
Heart failure (HF) is a condition that develops after the heart becomes damaged or weakened. HF occurs when the pumping action of the heart is not strong enough to move blood around, especially during increased activity or under stress. In addition, the heart muscle may not relax properly to accommodate the flow of blood back from the lungs to the heart. These abnormalities in heart function can cause fluid to back up in lungs and in other parts of body.
Preterm neonates ill-adapted to the extra uterine environment are prone to increased inflammation in multiple organs and the proinflammatory interleukine IL-1b has been closely implicated in brain injury associated with preterm birth (PTB). One major adverse neuronal outcome for PTB survivors is the greater propensity to develop ischemic brain lesions long after birth. Here, we hypothesize that the neural vasculature of premature infants becomes maladapted to appropriately respond to hypoxic-ischemic stress.
The internship will consist of studying, building, implementing and testing so called factors that are used to characterize the equities, commodities and currencies that the company invests in. These factors can be thought of as characteristics relating a group of securities that is important in explaining their returns and risk. My task will be first to understand the risk factors that are of particular importance to the company’s investment strategy.
Prostate biopsies can be difficult to interpret using standard pathology techniques. Because cancer can be fatal, the development of technologies providing complementary information could improve current pathology practice resulting in improved patient outcome. Raman micro-spectroscopy is a molecular imaging technique using backscattered light following tissue laser excitation to indicate whether or not prostate samples contain cancer cells. However, this technique is very sensitive to the molecules in chemicals used to process tissue (e.g. paraffin), which greatly limits its efficacy.