Extracellular nucleotides can favour inflammatory diseases via the activation of P2 receptors. The proinflammatory P2Y6 is the dominant nucleotide receptor in human and murine intestinal epithelial cells (IEC) and its expression increases during inflammation. Interestingly, we found that the blockade of P2Y6 totally prevented inflammation in the murine DSS model. This project will show whether and how the blockade of P2Y6 signaling in IEC can reduce, or even prevent, mucosal inflammation.
Muscle fatigue and associated perceived exhaustion are among the main barriers to physical activity and training adherence, which directly contributes to the spread obesity and cardio-metabolic diseases in Canada. While several dietary supplements claiming anti-fatigue properties exist on the market, a large number have not gone through robust scientific testing. The Radical Plus® product from Carpe-Diem Inc. is a liquid dietary supplement containing marine collagen, blueberry extract, and polyphenols.
The planned research program aims to address an existing gap: the lack of commercial availability of reference materials for food allergens to be used in the context of analytical method development, validation and performance testing. In particular, naturally incurred samples representing food matrices where priority allergens are likely to occur, in a controlled and calibrated fashion are not available. Allergens targeted include egg, milk as well as wheat gluten (targeting both wheat allergen and Gluten testing).
In vitro embryo production and embryo transfer (IVP/ET) is a technique that has been developed in cattle for genetic selection to enable rapid improvement in commercially important traits. Technological advances have resulted in a significant increase in the commercial use of IVP/ET in recent years, and have made this one of the fastest growing sectors in the dairy industries. However, pregnancy rates following the transfer of IVP embryos are lower than that of in vivo produced embryos.
This summer, Nathalia Soares Covre, a Mitacs intern from Brazil, is helping the modelEAU team develop a digital model of an innovative wastewater treatment process. This new process reduces the discharge of nitrogen into lakes and rivers so that plant operators can work to reduce the impact of urban wastewater on local ecosystems.
To work on the development of a tool enabling the measurement of blood oxygenation in the eye in vivo, using non-invasive methods. More specifically, the student involved will work on the development, implementation, and advancement of an algorithm for the measurements of oxygen saturation (through oxyhemoglobin content) in the retina.
Cyclin-dependent kinase-2 (CDK2) regulates cell cycle, whose structure and biological characteristics are well known. CRIF1 plays a regulatory role in the bone marrow microenvironment-induced leukemia cell cycle arrest through inhibiting CDK2. In this multi-disciplinary research, we will use a combined structure function study to reveal the interaction between CDK2 and CRIF1. This will facilitate the design of inhibitors for the interaction of the two important proteins, for eventual treatment of leukemia.
Online communities abound today, arising on social networking sites, on the websites of real-world communities like schools or clubs, on web discussion forums, on the discussion boards of videogames, and even on the comment pages of news sites and blogs. Some of these communities are “healthy” and foster polite discussion between respectful members, but others are “toxic” and devolve into virulent fights, trolling, cyber-bullying, fraud, or worse even, incitation to suicide, radicalization, or the sexual predation and grooming of minors.
Whether due to urbanization or climate changes, flood events have an impact on property value. Newly available geography data about flood risk zone have yet not been utilized to their full potential in Canada. This project aims to study the impact of the flood risk zone on the value of homes for Quebec City, and to identify other regions in Canada where similar conditions could affect housing value. The development of a strategy to expand the aim of research at the country-wide level will else be part of the project.
Several studies have shown that water levels of the Great Lakes would inevitably decline in a warmer climate. These studies were based on a modeling system that was not accounting for two-way exchanges of water and energy between the atmosphere and the earth surface, hence excluding key feedback mechanisms. The general objective of this project is to improve our understanding of the Great Lakes water resources and its sensitivity to climate change.