The indole subunit is a near-ubiquitous component of biologically active natural has become an important building block or intermediate in the synthesis of many pharmaceutical agents. Such as indole-3-carbinol, found in cruciferous vegetables has been shown to inhibit carcinogenesis. In this project I will focus on studying of action mechanism (cell apoptosis, angiogenesis inhibition and inhibiting microtubule formation) of indoles in breast cancer and prostate cancer. Establishment of models for the screening of indoles resources for resistance to breast and prostate cancer.

La résolution spatiale horizontale des modèles climatiques régionaux est à l’heure actuelle encore assez grossière, de l’ordre de la dizaine de kilomètres. Cette résolution engendre une sous discrétisation spatiale du cycle hydrologique continental, et donc une estimation approximative des échanges d’eau et d’énergie entre l’atmosphère et la surface continentale.

B. Gosselin and Doric Lenses Inc. have developed the first low-cost wireless head mounted optogenetic device enabling simultaneous biopotential recording and optical stimulation in the brain of freely moving rodents. This project aims at providing such a wireless optogenetic headstage system with user programmable functions, so it can address the dual nature of brain biopotentials, and become an essential tool for innovative research.

Pulse oximeters are key devices to provide early information on the respiratory and circulatory systems. In addition to be bulky and cumbersome, most commercially available systems lack a wireless connection, which cause numerous inconveniences. This project aims at designing a new wireless ring pulse oximeter which will enable to measure transmitted and reflected light from several locations around the finger to increase the quality of signal and gain more flexibility while improving comfort and ease of use.

Pharmaceutical companies are required to perform stability testing of their drug products by regulation. A drug product that succeeds on stability testing means that its identity, potency, and purity remain within pre-established limits over its shelf life. Nowadays, drug products are more frequently reformulated in response to a highly competitive market, new research discoveries and the availability of new suppliers of raw materials.

The project consists in devising a method to quantitatively describe textural features of ores; these features may include mineral composition, grain size and shape, spatial distribution, etc. Equally important is relating these features to the performance observed when processing the ores. The foreseen deliverable is a tool to predict ore processing performance. The scale of investigation is set at the rock and drill core size such that the performance prediction can be issued as early as possible in the ore dressing process.

Les variations anticipées du climat pourraient venir perturber substantiellement le régime hydrique québécois, appelant les acteurs locaux de l’eau à redéfinir leurs modes de gestion ainsi qu’à mettre en place des stratégies d’adaptation. Les travaux engagés dans ce sens, initiés dans le début des années 2000 par Hydro-Québec, s’appuient dorénavant sur une collaboration (cQ2 : Hydro-Québec, CEHQ, Rio Tinto Alcan, Ouranos) visant à diffuser un message complet et cohérent quant au diagnostic des impacts sur les régimes hydriques en s’appuyant sur des bases scientifiques solides.

Pharmaceutical companies are required to perform stability testing of their drug products by regulation. A drug product that succeeds on stability testing means that its identity, potency, and purity remain within pre-established limits over its shelf life. Nowadays, drug products are more frequently reformulated in response to a highly competitive market, new research discoveries and the availability of new suppliers of raw materials.

Le projet est l’utilisation de diverses méthodes pour déterminer la capacité thermique des matériaux.
Les applications directes sont :