Application of the Five Capitals Framework to the Mineral Resources Sectorof Mongolia to Support Sustainable Development

The overall goal of the proposed program is the co-development of education programs and academic research with opportunities to apply this understanding in context of SEF/industry activities. The outcomes will benefit SEF’s business activities in Mongolia and other developing countries with significant mineral resource potential. The program will also support investment and business opportunities for Canadian companies that are working in Mongolia.

Altitude & Heat - environmental synergies to optimize human performance - Year two

The environmental stress of altitude and heat have both been shown to elicit divergent adaptive responses and are used by elite athletes to augment training adaptation and subsequent performance. Indeed, 3-4 weeks at moderate altitudes can increase the body’s natural erythropoietin (EPO) responses, raising hemoglobin by 4-6% and enhancing endurance performance. Conversely, as little as 5-7 days of exercise induced heat acclimation can increase blood volume by 5-10%, resulting in increased tolerance to heat, increased VO2max /cardiac output and improve endurance performance as well.

TWN Cumulative Effects Monitoring Initiative: Ecosystem Modelling Framework

The general objective of the proposed activity is to increase the future productivity of Burrard Inlet and the contribution of seafood to the diet of Tsleil-Waututh Nation (TWN) members in support of the TWN Cumulative Effects Monitoring Initiative.

Molecular signatures and predictive biomarkers for phenotyping allergic rhinitis responses

Allergic rhinitis (AR) is in inflammatory disease characterized by nasal symptoms. It affects 20-25% of Canadians and is recognized as the most common allergic disorder worldwide. Patients can experience one of several types of responses to allergen onset hence a key hurdle to developing effective treatment plans is accurate diagnosis. The allergic responses are characterized by an early response, with a subsequent late response in a subgroup of patients. Based on severity of nasal symptoms, patients can be stratified as early responders, protracted early responders or dual responders.

Identification of blood-based biomarkers predictive of pulmonary exacerbations in cystic fibrosis

Individuals with cystic fibrosis experience recurrent episodes of worsen in respiratory symptoms, termed pulmonary exacerbations (PEx). Early identification of individuals who are at elevated risk of PEx can improve their clinical outcomes and rescue their lung function. In this project, we will collaborate with the Prevention of Organ Failure Centre of Excellence (PROOF) to develop a simple blood test to predict the PEx in CF individuals. We will also evaluate the genetic influence on blood biomarker candidates during the project and refine the blood test based on these genetic variants.

A Clinical Proteomic Test for Patient Care

There are 2.6 million Canadians with Chronic Obstructive Pulmonary Disease (COPD). COPD is a disease characterized by progressive loss of lung function that leads to shortness of breath, poor quality of life, reduced productivity, emergency visits, hospitalizations and mortality. The World Health Organization estimates that COPD will be the 3rd leading cause of death worldwide by 2030, accounting for more than 7 million deaths/year and 11,000 deaths/year in Canada.

A Clean Energy Plan for CleanBC: Informing the development of BC’s clean energy future

CleanBC is British Columbia’s recent climate strategy outlining how the province plans to transition from fossil fuels to a clean and renewable energy system. The plan contains targets that are meant to set a pathway towards a more sustainable future; however, Pembina Institute recently recommended that the government develop a clean energy plan to back up the CleanBC strategy by outlining more specifically how clean energy is going to be used to achieve the province’s clean energy targets (Riehl, Tam Wu & Kniewasser, 2019).

Blood flow within microfluidic conduits

A current area of focus at SMT Americas is to develop injection-moulding methods for medical lab-on-chip (LOC) devices, particularly to transport and process blood and plasma while eliminating conduits clogging and reducing sample loss. This project will evaluate the effect of flow conditions on viscosity of samples, and the adequacy of conduit structures achieved with SMT Americas’ technology for cell separation.

Validation of Selective Phytocannabinoids Using In Vitro Glaucoma Models

Glaucoma is the second leading cause of blindness in the world, mainly induced by increased pressure in the eye. Marijuana has been shown to reduce such pressure, thus benefit glaucoma patients. In the previous project, we screened several individual components from marijuana extracts and tested their ability on keeping cells alive. The current project puts an emphasis on neuroprotection and therapeutic aspects of glaucoma. We propose to target and analyse the effect of our selected compound for major downstream pathways that are significantly modulated in to Glaucoma pathology.

AccessiBelt - Car Seatbelt for Users with Limited Hand Dexterity

Our hand function can be affected by different diseases and disorders, such as arthritis and neurological injuries. Having limited hand function will immensely affect our life and will make everyday simple tasks challenging. There are about 1 million Canadians who reported struggling with daily activities due to this limitation. One task that is challenging for a person with limited hand function is buckling and unbuckling a car seatbelt. Car seatbelts are life-saving devices and are crucial for the protection of passengers in a car.

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