Understanding the regulation of specialized metabolite accumulation in hop plants (Humulus lupulus)

Hops (Humulus lupulus) flowers are most famous for imparting the bitter taste and aroma to beer. Hop flowers produce essential oils that contain many different plant compounds, which impart the characteristic taste and aroma of hop plants. However, how the production of these oils is regulated is not fully understood. The establishment of the craft beer industry, which is also rapidly expanding throughout North America and the world, is spurring renewed interest and investment in local hop agriculture.

Modulation of human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) ion channels and transporter activity, measured by atomic absorption spectroscopy (AAS)

During human clinical trials, a large percentage of candidate drugs fail because they are unsafe or ineffective. Even when preclinical cell and animal studies seem positive, problems occur because drugs tested with these models are often not predictive of what happens in humans. Many drugs, including non-cardiovascular drugs, target ion channels of the heart (membrane proteins through which heart cells conduct electrical currents), which can potentially result in lethal arrhythmias.

Advancing an Artificial Intelligence Platform for Crop-Health Monitoring

Plants can respond to changes in their surroundings and can convey precise information about their health state. Ecoation has developed a multi-sensory data acquisition device to capture this information and has been collecting in-field sensor data along with data labels produced by human experts during data collection. In addition, images of various parts of plant canopy has also been collected to supplement the sensory information and to provide insights into plant physical features such as vegetation.

Design, optimization and testing of baffle-type parallel-channel flow field plates within a 200-cm2 fuel cell short stack with a highly-active catalyst - Year two

Enhancing the current and power density in polymer electrolyte membrane fuel cells (PEMFCs) is one of the main challenges to their large-scale commercialization and hence in tune with the pending needs of the PEMFC industry. The volumetric power density in PEMFC stacks is strongly affected by the flow field plates due to their critical impact on the reactants distribution over the electrodes and their bulky size. In the proposed research, baffle-type parallel-channel cathode, anode and cooling flow field plates are designed with a small thickness.

Applied Mineralogy for Enhanced Processing of Gold Ore from Artisanal Mining in the Arequipa Region, Peru - Year Two

The proposed research has the objective of applying detailed mineralogical research to aid the multidisciplinary development of high speed sensors for real-time ore sorting applications. MineSense Technologies Ltd. is a mining technology company that develops such sensors and while they have successfully demonstrated the application of its core technologies to distinguish ore from waste material, continuing goals are to increase the number of non-grade parameters that can be detected, and therefore increase the breadth of the application of their technology.

Detection of insulin using a novel capturing system

Insulin is a hormone released from the pancreas, which controls the level of glucose in blood. Diabetes is a disease characterized by a lack of insulin production or impaired insulin action. Here, we propose the development of a novel system based exclusively on the measurement of insulin using capturing molecules with high affinity to insulin. This method will provide an affordable and simplified method to be used not only in point of care but also by the patient at home.

Creating shared value with communities in the early Mine life-cycle: The case of Erdene Resource Development Corporation in Mongolia

There is a significant body of research on Corporate Social Responsibility in the mining sector. However, little empirical data exists about what works well across stages of the mine life cycle, particularly during early exploration.

UPnGO with ParticipACTION: Evaluation of the implementation of a national workplace physical activity initiative

In order to improve the health and work productivity of Canadians, ParticipACTION developed a rewards based, PA tracking intervention called UPnGO with ParticipACTION. The UPnGO program aims to increase the amount of PA and decrease the amount of sedentary activities throughout the workday. Before and after the program, worksites will be assessed to determine what components of workplace environment and policy increase the success of the intervention measured by how employees use the UPnGO platform and changes in average daily steps.

A novel therapeutic drug for selective treatment of castration-resistant prostate cancer with MTAP deficiency

Chemotherapy is currently the most effective approach for treatment of advanced cancer. However, chemotherapeutics do not differentiate between malignant and normal cells, and lead to serious side effects. Recent findings indicate that a substantial proportion of cancers, as distinct from normal tissue, are deficient in an enzyme called methylthioadenosine phosphorylase (MTAP).

Assessing the validity of virtual simulation as a learning tool in the medical field. - Year 2

With the increasing prevalence of mobile devices, it is unsurprising that they are also being adapted for use as tools for learning and perfecting complex procedures. One of these uses is training health care providers through simulated medical procedures. Two important points should be considered when designing simulated systems to assess the efficacy and efficiency of these teaching tools. 1) Individual differences in emotional biases and learning profiles may necessitate personalized stimulus presentations within simulated environments to achieve optimal and translatable learning.