G protein-coupled receptors (GPCRs) are proteins present on the surface of a cell that are the targets of >30% prescription drugs. These GPCRs are involved in various diseases ranging from hypertension, airway diseases to taste disorders. Detection of antibodies for GPCRs in various disease states is a challenging task. The main goal of this project is to develop novel methods and improve existing methods to overexpress a couple of GPCRs for potential use in diagnostic assays. The industry partner, Acudex Inc.
The chicken egg represents an excellent source of nutrients, and the composition of the egg yolk can further be enhanced through modifications to the laying hen diet. While enhanced shell eggs are primarily sold as specialty eggs, an opportunity exists to add further value through the use of novel extraction technologies. The proposed research project will combine existing expertise in egg yolk enhancement with expertise in liquid/protein processing and extraction techniques.
A parallelized electromagnetic transient (EMT) simulation tool for power system transients will be developed in this research to accelerate the internal computation process. An EMT simulator uses a highly detailed representation for the power systems components. Conventional EMT simulators typically execute sequentially on a single processor; and computational effort increases significantly with network size. Graphics Processing Units (GPUs) have massively parallel architecture and can accelerate EMT simulation. The investigators recent Ph.D.
Biomass combustion is used to generate combined heat and power (CHP). The combustion furnace of this study (WiseWay) has been providing heat in small scales using wood pellets. The target of this project, however, is to upgrade the stoves design (for larger scale purposes and other biomass types) and integrate it with a steam microturbine (NextGrid). The resulting system is attractive to the environment and economy because it provides heat and electricity in one package, at a cheaper price compared with oil and gas, with less pollutants emitted.
With worldwide efforts to increase the utilization of renewable energy, traditional power distribution networks are being transformed into active distribution networks with the interconnection of distributed generation. The status of DGs connected to an active distribution network can change frequently, and this creates many challenges to network protection. The aim of this project is to implement a new protection solution for active distribution systems and microgrids in hardware and validate its performance.
In this study, an advanced frequency scanning method is used to extract the frequency dependent network equivalent (FDNE) impedance characteristic of a power electronic subsystem such as an HVDC transmission system or FACTS device including its controls. This is achieved by simulating it in the time domain on an EMT program, and exposing it to an energy dispersed chirp disturbance which has a broad harmonic spectrum. The impedance (or admittance) of this subsystem at the given operating point can then be determined using a Discrete Fourier Transform.
Fasting blood samples from persons with Peripheral Arterial Disease (PAD) and healthy individuals were previously collected during a prior Mitacs project.
A comparative analysis of the blood samples by metabolomics will be performed to identify potential biomarkers.
The intern will assist with the necessary correlation analysis for selecting compounds capable of serving as blood biomarkers for PAD.
Koven expects to directly benefit from the outcome(s) of this research by having the opportunity to commercialize any promising blood biomarker(s) into a diagnostic kit for early diagnosis of PAD.
Copy number variations (CNVs) are an important type of structural variation affecting pathogenesis of complex diseases, such as inflammatory bowel disease (IBD). Accurate detection of genomic regions with CNVs is crucial for understanding the etiology of IBD, as these regions contain likely drivers of disease development. Microarray technology provides single-nucleotide resolution genomic data and is considered one of the best measurement technologies to detect CNVs. This project will identify and characterize CNV in 340 IBD patients in Manitoba.
Natural fibres are abundant in Canada and have the potential to be used in a wide variety of biocomposites and industrial bioproducts. In order to develop a thriving biomaterials sector, the quality and consistency of this vast resource must be continually assessed and monitored to ensure a quality product can be delivered to end-users on a consistent basis.
The purpose of the project is to generate soybean plants able to tolerate whole plant submergence and waterlogging (soil submergence). This will be achieved by inducing Pgb, a gene normally present in soybean and known to confer tolerance to excessive humidity, through genetic manipulations. Correlative studies between Pgb expression and performance under excessive water conditions will also be conducted in commercial varieties of soybean. Similar studies will be conducted to assess the effect of altered Pgb level to drought stress.