Tunable Metal-Organic Frameworks for Detection and Capture of Phosphine and Other Hazardous Gases

This proposal aims to develop the next generation of smart materials to remove hazardous substances Canadians breathe in different environments from enclosed public buildings to industrial facilities. These hazards put the Canadians at risk, especially when in chronic contact even at low concentrations in the air. The Canadian company HFI Pyrotechnics Inc. and the University of Ottawa are partnering to contribute to the development of new filtering technologies against hazardous gases, which will assure the safety of HFI’s employees within their facility.

En Route to Discovery of Potential ‘Green’ Refrigerants

Refrigerants have a wide range of applications in Canada, from their support for the food industry (storage and transport) to their key role in recreational sports like hockey, curling and ice-skating. Although current hydrofluorocarbon refrigerants have solved previous problems associated with depletion of the earth’s ozone layer, they still suffer from high global warming potentials. More recently, these are being replaced by hydrofluoroalkene (HFA) refrigerants with considerably less global warming potential.

Shaping the immunogenicity and efficient range of oncolytic vaccinia virus by the programmed release of therapeutically active, self-amplifying RNA containing virus-like-particles

In this project, an oncolytic virus will be generated that combines the safety profile of vaccinia virus, with the immunostimulatory power of RNA-vaccines. Currently, the RNA-genomes of Alphaviruses are successfully used to encode proteins to be vaccinated against. Their special genome organization and makeup allow them to self-amplify within a cell. This replication in turn alerts the immune system to the host cell while creating an abundance of not only the antigen to be vaccinated against, but also therapeutically active proteins, e.g.

Engineering virus-based cancer therapeutics to drive a systemic anti-cancer immune response

One rapidly evolving area of cancer therapeutics is immunotherapy, which aims to drive a cancer-targeted immune response in tumors. Replicating virus-based therapeutics are a novel cutting-edge immunotherapy that have shown promise clinically. Turnstone Biologics has developed a novel cancer-killing virus with the capacity to deliver multiple payloads to further enhance the virus’ anti-cancer effects in the tumour microenvironment. Selection of the correct payloads will play a key role in determining how effective the virus is in treating a broad spectrum of patients.

Engineering Oncolytic Vaccinia Virus to Remodel the Tumor Microenvironment and Improve Efficacy of Combinational Cancer Therapies

Oncolytic viruses (OVs) are promising biotherapeutics that selectively infect and kill cancer cells. The efficacy of oncolytic viral therapy depends on the virus's efficient replication and dissemination within tumors. However, tumors often develop a dense extracellular matrix (ECM) surrounding their cells that provides resistance against many forms of cancer therapies including OVs.

Encoding Bi-specific T cell Engagers into oncolytic vaccinia virus

Through engineering and selection strategies, we have created novel cancer-killing oncolytic viruses (OVs) that are selective for tumours but are unable to grow in normal tissues. A critical component of the therapeutic activity of this class of therapeutics is the induction of an anti-tumour immune response, which can be suppressed in many tumours. One strategy to circumvent this problem is the use of Bi-specific T cell Engager (BiTE) antibodies that are able to force T cell recognition and killing of tumour cells.

Decision-making environment for optimal envelope retrofit of the office building

Energy-efficiency upgrades of existing buildings offer substantial energy and greenhouse gas emission reductions. Infrared thermography (IRT) of the building envelope is a non-destructive test that can be used to target retrofit actions and motivate energy efficiency improvements. Recent advances in IRT technology include using drones to collect thermal imaging data from the buildings efficiently, thoroughly, and without disturbing the occupants. The goal of this project is twofold.

A Deep Risk-Sensitive Reinforcement Learning Framework for Portfolio Management

In Finance, the use of Automated Trading Systems (ATS) on markets is growing every year and the trades generated by an algorithm now account for the majority of orders that arrive at stock exchanges. Historically, these systems were based on advanced statistical methods and signal processing able to extract trading signals from financial data. However, the recent successes of Machine Learning have attracted the interest of the financial community.

A Preliminary Overview of the Impacts of COVID-19 in the Republic of Malawi

Future Ancestors Services seeks to build a database that explores the teachings of various peoples around the world and what ancestry and ancestral accountability means to them in the context of current socio-political and environmental issues. This research project explores the ways in which the lived experiences of black people in Sub-Saharan Africa impact their experience and understanding of COVID-19, and how the disease has been harmful at not just a physical level, but also a spiritual and emotional level.

Accelerating Technical and Market Readiness of Solid-State Nanopores

Solid-state nanopores—small holes in thin membranes comparable in size to individual molecules—are promising candidates as sensors with which to revolutionize DNA sequencing, personalized medicine, point-of-care diagnostics, and next-generation information storage methods. A method by which these nanopores can be fabricated on an industrial scale was recently invented, but challenges remain, particularly in quality-controlling source materials with which to make them and in analyzing and interpreting the signals generated.