Orthosis modelling and fabrication

Orthoses are planar insoles for countering the constant and permanent deformations caused by muscular or nerve weaknesses. The orthosis fabrication process at VRAM currently involves five labor-intensive stages: the assessment of the gait, the determination of the corrective measures, the evaluation of the orthosis dimensions, the creation of hand-carved molds for forming the orthosis, and the forming and shaping of the orthosis using cork-based materials and resins.

A mixed-methods project investigating HerSwab™ and arts-based education as integral components of culturally acceptable cervical screening in Northwest Ontario First Nations communities

Specific strains of the human papillomavirus (HPV) can develop into cervical cancer. Screening for these types of HPV has been shown as a better early test for cervical cancer. Samples for HPV testing can also be collected by women without going into a clinic. This selftesting method may be a good cervical screening option for women who might not participate otherwise. Certain cultural groups, such as First Nations women, are less likely to participate in cervical screening than the general population. As a result, First Nations women have more diagnoses and deaths from cervical cancer.

Riberinhos’ Lived Experiences and Practices of Malaria in the Brazilian Amazon

In Brazil, malaria accounts for the highest morbidity registered in the Americas. In this country, 99.5% of the cases of malaria are registered in the Brazilian Amazon. The main goal of this research is to investigate how riberinhos experience and act upon malaria in endemic areas of Manaus and Careiro, State of Amazonas, Brazil. This study is situated in the fields of population health and medical anthropology. This study is situated in the fields of population health and medical anthropology.

Evaluation of viral sensitizer technology for improving influenza vaccine in an egg-basedmanufacturing process

Vaccination remains the most effective preventative measure for influenza infection. Seasonal influenza epidemics and the emergence of pandemic strains have increased the global demand for influenza vaccines, putting significant pressure on vaccine manufacturers. However, current vaccine manufacturing strategies rely primarily upon production in eggs, an age-old method that needs to be significantly improved. Recently, research from our lab identified a panel of novel compounds termed viral sensitizers (VSes) that increased virus production up to 1000 fold in cultured cells.

Aptamer-facilitated Virus Shielding (Apta?ViSh) Technology and Aptamer-facilitated AntivirusShielding (Apta-AntiviSh) Technology to extend the in vivo action of oncolytic viruses. Year One

This project aims to develop an aptamer-based technology to enhance the in-vivo survival of oncolytic viruses and thus the efficiency of virotherapy. Oncolytic viruses (OVs) can selectively replicate in tumor cells, leading to lysis of the tumor. OVs are particularly effective against metastatic cancers, which are especially difficult to treat conventionally. However, OVs can be deactivated by antiviral neutralizing antibodies (nAbs) and cleared from the circulation.

Development of Radio-Imaging Agents Targeting Necroptosis Year Two

The joint-effort project by Nordion Inc and the University of Ottawa Heart Institute aims to develop a series of radiolabeled necrostatin derivatives, which act as imaging agents based on necroptosis (programmed necrosis - a type of cell death) inhibitors to help diagnose disease (such as cardiovascular, neurological diseases and cancer) and monitor their treatment effects. The roles of the fellow are to design, synthesize and characterize these agents and to assist in testing their biological properties through further in vitro and in vivo evaluation.

Detection and prevention of preeclampsia using metabolomics and Vaccinium leaf extract for human trophoblast survival

Blueberry leaves are gynaecological aids and inhibitors of advanced glycation endproducts (AGEs). AGEs cause atherosclerosis, kidney, vascular, and neurological diseases through an oxidative process and correlate with preeclampsia. Preeclampsia affects 2-7% of women and is a leading cause of maternal/perinatal mortality. A woman dies of preeclampsia every eight minutes worldwide. Unfortunately, randomized trials evaluating dietary, vitamin, mineral treatments showed minimal benefit in reducing preeclampsia. AGEs are associated with preeclampsia.

Development of thyroglobulin specific aptamers for detection of thyroid carcinoma in the presence of thyroglobulin specific auto-antibodies

Thyroid cancer is the most frequent endocrine cancer. Over 90% of thyroid cancers are of the follicular or papillary type termed differentiated thyroid carcinoma (DTC). Thyroglobulin (Tg) serum measurement is an integral part of the follow up and management of DTC patients. Serum Tg levels are conventionally measured using either an immunometric assay (IMA) or radioimmunometric assay (RIA). Both methods rely on the use of labeled exogenous antibodies.

Development of Radio-Imaging Agents Targeting Necroptosis

The joint-effort project by Nordion Inc and the University of Ottawa Heart Institute aims to develop a series of radiolabeled necrostatin derivatives, which act as imaging agents based on necroptosis (programmed necrosis - a type of cell death) inhibitors to help diagnose disease (such as cardiovascular, neurological diseases and cancer) and monitor their treatment effects. The roles of the fellow are to design, synthesize and characterize these agents and to assist in testing their biological properties through further in vitro and in vivo evaluation.

Development of a Process for Manufacturing Synthetic Hydrocarbon Fuel from Captured Carbon Dioxide

This project would seek to develop an integrated system incorporating a reverse water gas shift (RWGS) reactor to convert carbon dioxide and hydrogen into carbon monoxide and water, aiming for maximum production of carbon monoxide. RWGS is an endothermic, catalytic, equilibrium-limited reaction, so the project team will seek to develop efficient, novel catalysts and supports, an optimal reactor design, and an efficient separation/recycling system so as to minimize wastage of unreacted raw materials.

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