Multiplexed quantitative proteomics approaches to characterize residual host cell protein impurities in biopharmaceutical processing

Many drugs, such as those made of antibodies, are produced using cells from bacteria and other organisms. Companies such as BioVectra use this approach to produce antibody drugs efficiently and cost-effectively. At the end of the production process, residue such as protein from the “host” cells (called host cell proteins, or HCPs) must be removed from the antibody. Although methods are currently available to test for HCPs, they do not fully identify all those present. Furthermore, how drug production processes effect what HCPs are present is not known.

Immersive Virtual Environment for Dental Restorative Techniques

Dentists and dental assistants are required to complete continuing education. Blue Light’s first technology introduced in 2010 was a patient simulator used for teaching hands-on light curing skills. This technology incorporates a mannequin head, expensive electronics and required an in-person course which is less desirable in the current covid-19 landscape. Exploring other mediums to deliver required educational training will be important over the next foreseeable future.

Soil, Water and Topography Maps as a Management Tool to Improve Profitability and Sustainability within the Potato Industry

The proposed research will explore opportunities in measuring spatial variability in soil, water and topography within potato fields. Addressing this variability by doing site specific application of inputs such as fertilizer, crop protectant and seed can help to increase environmental sustainability and economic viability in potato production. This research will help develop new applications for SWAT mapping in potatoes all over the world.

bridgeVUE – leveraging emerging technologies for safer and more efficient marine navigation.

Navigation at sea is a complex and comprehensive task. Combined with the challenges of navigating in heavy traffic, and avoiding dangers in low light and low visibility, it becomes considerably more difficult. This project, bridgeVUE, leverages an emerging technology to enhance marine navigation by contextualizing radar data over an individual’s field of vision, in real time.

Development of Biodegradable Soft Bait Fishing Lures from Natural Materials

There is an increase in reporting of angling activities linked to environmental pollution and exploitation. Soft plastic lures (SPLs) are a major pollution source arising from recreational angling. A small portion of SPLs currently commercially available are designed to be more environmentally friendly alternatives to PVC as they are biodegradable and are manufactured using natural and/or food-grade ingredients. Moreover, these natural lures can successfully degrade in water and are thus more likely to be passed through the digestive tracts of aquatic organisms.

Development of biomarkers to assess health impact of exposure to algal toxins in Atlantic salmon (Salmo salar) and effectiveness of mitigation measures at marine open-pen salmon farms

Atlantic salmon are Canada’s top aquaculture export and contribute $1.5 billion annually to British Columbia’s (BC) economy. In BC, blooms of toxic algae are a common problem for salmon farmers, often resulting in large production losses due to lost growth and disease with high mortality. I recently identified for the first time at BC fish farms two algal toxins, domoic acid (DA) and okadaic acid (OA) that are likely associated with mortality at these sites.

Effect of off-bottom oyster aquaculture on coastal bird populations

The coastal ecosystem of Prince Edward Island (PEI) represents an interface between the open marine waters of the Gulf of St. Lawrence and the sandstone, densely populated province of PEI. It is one of the wildest landscapes remaining in PEI and hosts several species at risk (including the endangered piping plover and red knot). This research is part of a larger project to more fully understand the dynamics of coastal ecosystems.

Delineation of Soil Management Zones for Subsoiling to Mitigate Soil Compaction Effects on Soil Properties and to Optimize Crop Yield

The proposed research investigates an opportunity of monitor, measure, and model the role of carbon sequestration and emission of carbon dioxide from agricultural soils of Atlantic Canada. Precision agricultural practices will be designed to promote sustainable agriculture in Atlantic Canada.

Turn-Key Robot Motion Planning Solutions

To increase the speed at which companies can develop robots we plan to create a package containing a number of key path-finding programs which can be easily connected with any robot. This will make it easier to produce both commercial and experimental robots without the need to create a path-finding program unique to the robot. We also plan to evaluate the possibility of offering expert assistance in choosing and tuning the available programs included in the package.

Using drone and remote sensing technology to increase profitability and climate resilience of potato production

Potatoes are among the top five crops worldwide. With the rate of climate change accelerating, the pressures on potato production systems (e.g., heat stress, water stress, pest pressures) will intensify adaptation efforts. Although climate change is already happening, it is often seen as an abstract and distant problem that diverts resources from current production challenges. However, drone and remote sensing technology can reconcile this false dichotomy. They can help growers better respond to crop needs with targeted use of inputs, which improves the bottom line.

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