Optimizing heuristics for spin-glass problems for diverse solutions

Optimization problems, such as finding the shortest or fastest path to a destination are ubiquitous in industry. Hower, for some industrial applications it may be desirable to have a set of few diverse, yet nearly optimal solutions. The goal of this project is to create new optimization problem solvers that focus on both quality and diversity of the solutions proposed. These solvers will subsequently be used to assess the performance of the D-Wave quantum annealer processor.

Thermal Performance Study of Switch Module Redesign

Thermal analysis is performed on a proposed design change on electronic assembly to ensure that it meets customer requirements (temperature ranges) and is a more cost-effective design. Such design change should be cost efficient. The important aspect, in addition to the design, is interacting with different engineers at different positions in the company. Working with mechanical engineers and suppliers in achieving such targets and ensuring the work done is viable and on track.

Quantum Resources Required for GKP Qubits

Qubits are fundamental units for quantum computation. Photonics is a promising physical medium to realize large-scale quantum computation. One proposal to realize photonic qubits was proposed by Gottesman, Kitaev and Preskill (GKP). Here, the logical qubit is encoded into states of a bosonic mode or a quantum harmonic oscillator. It is expected that such a procedure will lead to a better quality and number of qubits.

Enabling next generation cardiac therapeutics with genetic engineering and novel in vivo models for cardiomyocyte transplantation

The development of cellular therapeutics is acutely dependent on the ability to evaluate the functional characteristics of the cells in predictive animal models. This forms the basis of key pre-clinical data packages that are key for regulatory submissions preceding human clinical trials. The development of appropriate model systems, the execution of the surgical techniques to deliver cells to the target tissue, and the techniques to functionally analyze these cells in situ are technically challenging.

Validation of Novel, Tumor Microenvironment-based Targets for Biological Therapeutics

ImmunoBiochem is developing novel anti-cancer therapeutics to address unmet need in intractable solid tumors. Because solid tumors are highly heterogeneous and evasive, recognizing cancerous cells, while avoiding damage to normal tissue, is a challenge. As a result, many targeted therapies quickly come up against resistance, resulting in patient relapses. ImmunoBiochem is solving the issue of tumor versus normal recognition by exploiting cancer targets in the tumor environment – a collection of features that are uniquely present in tumors and absent in the environment of normal cells.

AI-powered operating system for buildings: new performance metrics

In the real estate sector, a large volume of data is produced by businesses, commercial users and building visitors in a great variety of forms. For instance, three extensive sources of data come from unstructured text (e.g. documents, contracts), numerical data containing resources consumption and sensor/image-type data describing user behavior. A challenging problem for the sector is how to process the generated data into a useful asset that can provide insights to help business decisions, optimize user navigation and automate building-related processes.

Optimization of astaxanthin production in large-scale cultivation of microalgae by utilizing industrial CO2 emissions - Year two

Haematococcus pluvialis is a green microalga that concentrates the compound astaxanthin, a commercial product with nutraceutical, pharmaceutical, cosmetic, aquaculture, and food applications.

Security protocols for cloud-based noisy intermediate-scale quantum computers (NISQ): development and implementation.

AgnostiQ Labs is looking to develop immediately applicable encryption/obfuscation techniques for quantum computing. At present, encryption protocols developed in academia are unsuitable for real-world applications because they largely depend on quantum hardware that do not yet exist.

Going On-line with Cognitive Rehabilitation: Testing and Implementing Web-based Goal Management Training at Clinical and Commercial Levels

Goal Management Training® (GMT) is a Baycrest cognitive intervention that has been studied extensively, applied clinically, and manualized into kits for clinicians that have been commercially available since 2012. GMT targets executive functions, a collection of higher-level abilities involved in planning, organization, strategy, and inhibition. Executive impairment can be seen in normal aging as well as in numerous neurological conditions, including dementia and traumatic brain injury (TBI). GMT is the gold-standard treatment for executive impairment worldwide.

An investigation of Ontario ESL teachers’ strategies and perceptions for teaching Chinese international students in Ontario public schools.

Recent rapid increase in the number of Chinese international students with English as a second language (ESL) attending Canadian schools has led to the exploration of in-service ESL teachers’ teaching strategies towards these students. Working with View-Wide International Education Group and using multiple case studies, this study will articulate the nature and challenges of ESL teaching and identify various ESL instruction means.