Part 2 (extension): Long-term evaluation of corticosteroid-releasing formulations to suppress implant device- related foreign body reactions and fibrosis

Implanted medical devices have dramatically improved the lives of millions of patients worldwide. However, in many cases, the body’s immune system rejects these devices and encapsulates the implant in fibrous scar tissue. This reaction is most detrimental to sensors for continuous monitoring and treatment of chronic conditions such as diabetes and those of the central nervous system. Device functionality is usually severely limited and risky additional surgeries for implant removal and reinsertion are required.

Chemical targeting of HDAC6 as a strategy for anti-viral drug discovery

The emergence of viral pandemics, exemplified by the Coronavirus Disease (COVID-19), has exposed the urgent need for the development of viral infection therapeutics. In a short span of time, more than 1.5 million individuals have been infected and there have been nearly 90, 000 deaths worldwide. Our objective is to pharmacologically validate a new strategy for viral infection therapeutics by designing molecules that inhibit HDAC6, a protein implicated in viral entry.

An Investigation of Service Mesh(es) and Security Models Within and Across Multiple Distributed Systems

Global service providers in highly regulated financial sectors must accommodate an ever-changing, sometimes competing, landscape of regulatory concerns. This project seeks to determine a reasonable path forward in technology design and adoption to accommodate current and anticipated infrastructure changes. Moreover, bridging the service layer across multiple, distinct distributed systems of varying complexity will pose new challenges while performance and observability of these systems become critical consideration.

Road Accident Severity Detection using Telematics and Environmental Data from Connected Vehicles

Road safety affects everyone, not just Geotab customers. With several years of driving and environmental data collected from over 2 million connected vehicles, there is a great opportunity to leverage big data and machine learning to establish an accident detection system. On top of driving data and environmental data, it also contains machine diagnostic data which is hypothesized to have highly correlated features when it comes to accident detection.

SOTI SNAP Widget Enhancement

SOTI has developed a software product called SOTI SNAP that allows anyone to create an app with no programming or technical knowledge. SOTI SNAP allows users to create apps by dragging and dropping widgets onto a canvas and connecting them together to create an app. The research problem to be addressed is to solve customer challenges by first understanding what the customer is asking for, then research on what is the best way to meet their needs, and finally, create brand new or enhance existing widgets so anyone can use them easily and effectively.

WiFi Indoor Localization and Geofencing

Many mobile devices that are used in an enterprise are considered mission critical as they are heavily relied upon, allowing a worker to do their job. Locating these devices anywhere and anytime becomes that much more important, especially if they become lost or stolen. SOTI’s technology leverages GPS on a device to track its location and can also alert if a device leaves/enters a predefined geographical fence on a map, otherwise known as geofencing. Outdoor and GPS based geofencing is widely adopted by many SOTI customers, yet indoor location and geofencing remain relatively novel.

3D imaging of solid state batteries

Battery technology is vital for storing renewable energy, which is inherently intermittent. In order to match these intermittent energy sources (such as the wind and sun) to real world patterns of use, we need reliable and durable energy storage technologies. Increasing the energy density and range of operating temperatures are much needed advancements for next generation batteries. Currently safety issues accompany efforts to increase the energy densities of mature liquid electrolyte based batteries.

Developing a regional approach to modelling the co-benefits urban forest ecosystem services provide.

As the intensities of urbanization and climate change increase across the Toronto region, there are many benefits pointing to a need for increased investments in our regions urban forests. Urban forests provide co-benefits, services that benefit both humans and the environment, through heat mitigation and mitigation of the “urban heat island”, removing air pollution, sequestering carbon, managing storm water run-off and flood reduction, as well as benefits to both physical and mental human health.

Nano-engineered concrete and composites with advanced graphene-based 2D nanomaterials

The development of high performance and durable concrete material is extensively required in the present world to build resilient and sustainable infrastructure. This project will open the prospects for developing a high performing advanced concrete composite engineered with graphene-based nanomaterials. Graphene is a nanomaterial typically produces from graphite, with extraordinary strength and chemical properties. The partner organization in this project is ZEN Graphene Solutions Ltd., the owner of a large high-quality graphite mineral in Thunder Bay, Ontario, Canada.

Machine learning in the operating room: focus, performance, and the medical record

This proposed study will significantly enhance our current understanding of how specific intra-operative factors can impact patient outcomes. Our proposed work will provide a proof of concept that machine learning can objectively predict a specific, high-impact post-operative complication, allowing us to move forward with scaling this work to a wide variety of surgical settings.

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