Mechanical study and failure analysis on steel spirally tungsten inert gas (TIG) welded tubes

Spiral tubes and rings have been broadly used in the manufacturing sector, especially for the automobile industry. However, the failure of the rings will significantly shorten the service life of components, even leading to a disaster when the part is under operation. Generally, these tubes and rings are made from steel sheets spirally using the tungsten inert gas (TIG) welding method.

Assessing the impact of cell positioning via micropatterning on throughput, precision, and reproducibility of cell-based tests

In recent years, the concern with data reproducibility in preclinical research data has increased significantly. A survey performed by Nature showed more than 70% of published research is not reproducible and the issue is more concerning when it comes to biomedical research with only 10% of published work able to be reproduced. Scientists study the effect of drugs on cells before human trials and market entry.

Machine learning-based optimization of a small-molecule suppressor of the cellular prion protein

A reduction in the levels of the cellular prion protein (PrPC) is expected to ameliorate cellular toxicity in both Alzheimer’s disease (AD) and prion diseases. The latter are invariably fatal diseases that include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy (BSE), also known as ‘Mad Cow Disease’, in cattle. To identify a rational method for reducing PrPC levels, the Schmitt-Ulms group has been studying the evolution, function and molecular environment of PrPC for more than ten years.

Stratifying colorectal cancer liver metastases using unsupervised clustering of quantitative imaging phenotypes

Personalized and precise treatments are the keys to improve prognosis of cancer patients and are also the main strategy of Sunnybrook Hospital. This project aims to stratify patients with colorectal cancer liver metastases (CRM) based on their disease subtype and risk using magnetic resonance imaging, which is routinely used in the diagnosis, staging and operative planning.

Assessing and Identifying Clinical Dead-ends in Intensive Care Settings

type of treatment they will provide to patients. With technological improvements and the availability of a significant volume of data, it is increasingly difficult for care providers to properly evaluate and analyze the options available to them. The current health condition of the patient--reflected in the monitored observations which are recorded in EMR--may depend on all the relevant information from all prior observations and selected treatments, not just those most immediate (e.g., the trend of various health measures).

Predicting Warfarin Sensitivity after Cardiovascular Surgery

Anticoagulation with Warfarin is indicated and required for post-operative cardiovascular patients. However, it is a high-risk medication with a narrow therapeutic range where sub-optimal dosing can lead to complications and even death. While multiple risk factors have been associated to Warfarin sensitivity, the prediction of optimal Warfarin dosing strategies remains ineffective and requires trial and error and close patient monitoring.

Developing an affordable north seeking gyroscopic compass for aerospace, construction, mining and tunneling applications

ApoSys is applying the new method to develop an affordable north seeking gyroscopic compass for multiple applications. The cost of such device is too high to be used in many industrial processes. For example the mining industry the device is shared by a few groups of workers to reduce the cost. It has problems for the long standby time, low productivity, and increased cost. The similar scenario is exiting in other industries. Our innovation will make the same standard device with 30 to 50% cost so that it will help improve the productivity and save labor, time and money for customers.

Improving Service Life of Graphite Component Through Advanced Coating

Kelvin Thermal Storage is developing a technology to convert the inexpensive, off-peak/excess or renewable energy into a thermal energy. The technology uses graphite as the heat storage media and carbon composites as heating elements. In order to protect the carbon based components from oxidation by the heat-carrying media (an inert gas containing trace amounts of oxygen), coating of the elements is proposed and being investigated in this work.

Health Equity and Barriers to LDKT in South Asian Communities

As of 2012, about three million Canadians suffer from chronic kidney disease. Patients with kidney failure need dialysis or kidney transplantation to survive. LDKT (LDKT) is the best treatment option for many patients with kidney failure, however, it is not used as much as it could be. Patients who belong to ethnic minority groups are less likely to receive LDKT compared to Caucasians. Currently, there is limited research to help us better understand what prevents access to LDKT in patients from the South Asian community.

OPTIMIZATION OF A HEAT TRANSFER SYSTEM

Heat exchangers, used in building heating, ventilation and air conditioning (HVAC) systems to transfer heat from hot to cold fluids, are designed to operate under ideal conditions. However, in practice operating conditions may vary with ambient temperature or humidity. HVAC system efficiency can be improved significantly if fluid flow rates are adjusted in response to such changes. Armstrong Fluid Technology is a Canadian firm that has developed control systems to adjust the flow through building heat exchangers to maximize their efficiency.

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