Development of a tele-health rehabilitation system to provide automatic assessment of patients’ performance, improve patients’ adherence and enable remote rehabilitation-Phase I

Poor physical recovery, especially in remote rehabilitation, is the problem that will be addressed in this project.
This project is Phase I of development of Fun-exercise module. Fun-exercise system uses gamification to boost patients’ adherence to their prescribed home-exercises. To achieve this goal, Fun-exercise will use mentally stimulating and customizable games paired with a set of wearable sensors to provide feedback to ensure activities are being done correctly. In phase I, patient study and conceptual design of the Fun-exercise module will be undertaken.

Investigating continuous miners’ performance at Goderich salt mine to minimize the generation of fine particles

Continuous miner (CM) optimal performance depends upon various factors which controls the rock-bit (cutter) interaction, including the type and geometry of the bits (cutters), operational parameters (drum speed, advance rate and etc.) and geological setting of the target rock. According to the conducted investigation on CMs performance at Goderich mine, although, these machines have improved the production rate significantly, fine particle (

Development of Advanced Treatment Methods in Gamma Knife Radiosurgery

This research focuses on two advanced treatment methods for Gamma Knife radiosurgery, primarily used to treat brain tumours, to bring both methods closer to clinical implementation. Dose painting uses medical images for prescriptions to individual voxels (small volume cubes), and tailors treatments to each patient’s tumour biology. Dynamic treatment involves continuously moving the patient while delivering radiation, which may reduce treatment times and improve dose uniformity in treating larger tumours.

Development of Advanced Alkaline Stable Electrocatalysts for Alkaline Membrane Electrolysers

The proposed research will advance novel electrocatalysts developed and tested at the University of Toronto into pilot scale testing facilities at DCL International. The work will demonstrate the stability and catalytic activity of these novel materials in the developing field of hydrogen generation using alkaline membrane electrolysis.

Development of Smart Furnitures Using Non-Contact ECG Textile Sensors

In collaboration with Vee Canada Inc and Sona College of Technology and Vee Technologies in India, we propose to create a noncontact Electrocardiography (ECG) monitoring system embedded into different furniture such as a bed and chair for fully sensing and processing human heart activity using textile-based sensors and machine learning modules. The project's ultimate goal is to continuously track human heart activity, i.e., to measure ECG signals. Furthermore, a pressure sensor mat will be used to follow the seating activity for further processing.

Situation awareness in complex medical decision-making

Medical errors continue to occur in the Canadian healthcare system, with errors not only leading to patient harm but also to costly litigation. Some of the costliest litigation relates to low frequency, but high impact, events. The aim of this research will be to design, and assess the feasibility of, interventions that can lead to fewer costly medical errors by improving the situation awareness of medical personnel. We will first examine the behavioural traits of the people who are cited in medical litigation cases.

Generation of integration-free, high-quality iPS cell lines from a non-invasive, accessible tissue source, the plucked hair follicle

In theory, hair cells will be reverted back into stem cells and then pushed towards pancreatic progenitor cells to create pancreatic organoids. The goal of the project is to pluck hair follicles from individuals across Canada, cryogenically preserve them and use those follicles towards reprogramming. We want to determine whether or not we can create high quality iPS cell lines using a tissue source which can be obtained anywhere in the world, without a painful procedure. If successful, this would mitigate the burden of cell collection with respect to autologous iPS- based therapies.

Revealing the mechanism behind word-finding difficulties in older adults as detected by speech analysis software

When we get older, we tend to experience difficulties naming people, locations, and objects around us more frequently. Word-finding difficulties like these are not only sources of frustration but also crucial indications of a general cognitive decline. The company Winterlight Labs developed a software that analyzes natural speech for detection of cognitive decline and found that word-finding difficulties can be important cognitive indications.

Targeting the ubiquitin system function through GID4 - Year two

Protein turnover is an incompletely understood aspect of biology, important for various processes including adaption to environmental stimuli. Over 500 protein complexes (E3 ligases) are involved in marking proteins for degradation, but only a small number of these E3 ligases are well characterised. The current project seeks to develop chemical inhibitors of GID4—a key component of an E3 ligase complex called C-terminal to LisH (CTLH). This E3 ligase is thought to play a role in nutrient sensing and autophagy, which are both implicated in chemotherapy resistance of cancer cells.

Manipulating the Nutritional Content of Red Algae through Process Variables for its use in Pet Food

To redesign our food systems to be more sustainable, the need for novel, nutritious and sustainable ingredients is pressing. In the context of pet food, livestock and fish ingredients are the main contributors to the environmental impact and thus, present the most potential for impact reduction if they were removed from pet food formulas. However, meat and fish can provide key ingredients in pet food that are either absent or in very low concentration in plants, e.g. taurine and arachidonic acid.