Stratifying colorectal cancer liver metastases using unsupervised clustering of quantitative imaging phenotypes

Personalized and precise treatments are the keys to improve prognosis of cancer patients and are also the main strategy of Sunnybrook Hospital. This project aims to stratify patients with colorectal cancer liver metastases (CRM) based on their disease subtype and risk using magnetic resonance imaging, which is routinely used in the diagnosis, staging and operative planning.

Assessing and Identifying Clinical Dead-ends in Intensive Care Settings

type of treatment they will provide to patients. With technological improvements and the availability of a significant volume of data, it is increasingly difficult for care providers to properly evaluate and analyze the options available to them. The current health condition of the patient--reflected in the monitored observations which are recorded in EMR--may depend on all the relevant information from all prior observations and selected treatments, not just those most immediate (e.g., the trend of various health measures).

Predicting Warfarin Sensitivity after Cardiovascular Surgery

Anticoagulation with Warfarin is indicated and required for post-operative cardiovascular patients. However, it is a high-risk medication with a narrow therapeutic range where sub-optimal dosing can lead to complications and even death. While multiple risk factors have been associated to Warfarin sensitivity, the prediction of optimal Warfarin dosing strategies remains ineffective and requires trial and error and close patient monitoring.

Developing an affordable north seeking gyroscopic compass for aerospace, construction, mining and tunneling applications

ApoSys is applying the new method to develop an affordable north seeking gyroscopic compass for multiple applications. The cost of such device is too high to be used in many industrial processes. For example the mining industry the device is shared by a few groups of workers to reduce the cost. It has problems for the long standby time, low productivity, and increased cost. The similar scenario is exiting in other industries. Our innovation will make the same standard device with 30 to 50% cost so that it will help improve the productivity and save labor, time and money for customers.

Improving Service Life of Graphite Component Through Advanced Coating

Kelvin Thermal Storage is developing a technology to convert the inexpensive, off-peak/excess or renewable energy into a thermal energy. The technology uses graphite as the heat storage media and carbon composites as heating elements. In order to protect the carbon based components from oxidation by the heat-carrying media (an inert gas containing trace amounts of oxygen), coating of the elements is proposed and being investigated in this work.

Health Equity and Barriers to LDKT in South Asian Communities

As of 2012, about three million Canadians suffer from chronic kidney disease. Patients with kidney failure need dialysis or kidney transplantation to survive. LDKT (LDKT) is the best treatment option for many patients with kidney failure, however, it is not used as much as it could be. Patients who belong to ethnic minority groups are less likely to receive LDKT compared to Caucasians. Currently, there is limited research to help us better understand what prevents access to LDKT in patients from the South Asian community.

OPTIMIZATION OF A HEAT TRANSFER SYSTEM

Heat exchangers, used in building heating, ventilation and air conditioning (HVAC) systems to transfer heat from hot to cold fluids, are designed to operate under ideal conditions. However, in practice operating conditions may vary with ambient temperature or humidity. HVAC system efficiency can be improved significantly if fluid flow rates are adjusted in response to such changes. Armstrong Fluid Technology is a Canadian firm that has developed control systems to adjust the flow through building heat exchangers to maximize their efficiency.

Imaging MAO-B in Cannabis Use and Cannabis Use Disorder with Positron Emission Tomography (PET)

Cannabis is the most commonly used drug worldwide. However, there is limited understanding of factors supporting cannabis use (CU) and the development of cannabis use disorder (CUD). There is also a clear association between mood disorders and CUD, but the mechanism underlying this relationship is unclear. There is evidence that major depression is associated with elevated monoamine oxidases (MAO). Tobacco use is also associated with an inhibition of MAOs (both subtype A and B). Our hypothesis is that the same inhibition is happening in the brain of people exposed to cannabis.

Modeling Exfiltration Events in Sunlife Cybersecurity Data

Many governments and other organizations hold confidential data. Theft of that data can be extremely damaging both to the organization and to the people whose data has been stolen. Massive breaches each involving millions of people have been occurring on a regular basis in recent years. New Cyber Security tools are needed to help people determine the threats that exist and to provide active online monitoring that can detect unusual behavior as it happens.

Automatic Adjustment of Photometric Camera Parameters to Improve Visual Motion Estimation

Cameras are a fundamental component of modern robotic systems. As robots have become relied upon for safety-critical tasks, the need for robust sensing is apparent. Cameras have a major limitation, compared to other sensors such as LIDAR, in high-dynamic-range environments where lighting conditions rapidly change. These changes can cause visual navigation algorithms to struggle and, in some cases, fail in instances where images become severely under- or overexposed.

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