Acute myeloid leukemia (AML) is a blood cancer with very poor prognosis, especially for patients older than 60 years of age. This is in part because of the severe toxicity of medicines available. Less harmful medicines are needed to better treat older patients. Therapure Biopharma Inc. has chemically linked the standard toxic chemotherapy medicine called cytarabine to the blood protein hemoglobin to make a potentially safer and more effective medicine to treat AML. In collaboration with the University Of Waterloo School Of Pharmacy, Therapure Biopharma Inc.
Over the last few years, the data revolution occurred with the emergence of Big data. In medical field, the term big data refers to large databases in terms of patients and/or information from varied sources. Nevertheless, heterogeneity is encountered in this kind of data. Indeed, data arise from different medical centers. Furthermore, we cant perform traditional statistical methods on these large databases: major problem are multicollinearity and overfitting. Lots of regularization methods have been proposed in order to adapt classical methods. Mittal et al.
Stress is a top workforce risk and according to a Towers-Watson 2013 survey, half of all employers identify improving the emotional and mental health of employees as their top priority for building health and productivity programs. The objective of this research is to improve StressWelliQs systems and product portfolio by creating gamified technology solutions and thereby improving the lives of Canadians. The creation and evaluation of this technology will allow StressWelliQ to create a more effective augmented stress management platform.
Eye diseases, such as dry eye syndrome, affect about 15% of the population. Eye drop formulations are the most common way to treat eye diseases, but patients struggle with the multiple daily applications required and the resulting side effects. Our goal is to develop an eye drop formulation that requires less frequent application using nanoparticle drug carriers. Drugs are quickly cleared from the eye due to blinking and tear turnover, but these nanoparticles can attach to the corneal surface to prevent rapid clearance.
"A large majority of microbes cannot be cultured. Recently, microbiome sequencing has begun to identify the genetic potential of these lineages, often referred to as microbial dark matter. By integrating my taxonomic profiling methods with function profiling developed by the academic supervisor, I aim to develop and apply a comprehensive pipeline for microbial dark matter characterization, placing unclassified taxa into both a taxonomic and functional context.
In this research we are aiming to build smart wearable and standalone units which can be used in our everyday lives for things such as: i) tracking vitals, and storing information; ii) monitoring sporting activities; iii) collecting ambient (in house and in air) statistics for smart home monitoring systems; iv) location tracking; v) emergency response .... .These wearables and stand alone devices have the advantage of not being connected to battery and can harvest its required energy from motion and sun light.
During physiotherapy a continuous assessment and progress tracking of a patients performance is of clinical interest. In this project, based on the promising results from the initial prototype, we will redesign the wearable sensors to improve tracking accuracy, communication speed and robustness, incorporate onboard data storage and computation, and minimize cost and size. Furthermore, we will develop automated algorithms for the analysis of the measured data to help physiotherapists identify the causes of changes to the patients' movement profile.
H2O4All is one of many small, non-governmental organizations (NGOs) working to address the needs of the 663 million who lack access to safe drinking water and the 2.4 billion who are without access to sanitation facilities in low- and middle-income countries. Unfortunately, evaluation of water, sanitation, and hygiene (WaSH) interventions are rarely a priority for NGOs like H2O4All whose projects are time and budget sensitive; this is concerning because without evaluation we cannot determine H2O4Alls impact on the communities in which it works.
Obesity and diabetes are a significant global burden and there is an immediate need for novel treatments and management strategies. Our lab has shown that an avocadoderived lipid is a potent inhibitor of fatty acid oxidation (i.e., the cellular breakdown of fat for energy) which reduces mouse weight gain without toxicity. Inhibition of fatty acid oxidation for the management and treatment of obesity and diabetes is an established therapeutic strategy. The objectives of this project are two-fold.
CO2 is a greenhouse gas that impacts climate change. The Carbon Upcycling Technologies has developed a technique to attach gaseous CO2 molecules to graphite. In this project, this graphite will be converted to graphene using chemical oxidation methods. The one-atom thin monolayer graphene oxide will have potential applications in variety of industries, such as waste water treatment, gas separation and reinforcement of plastics.