Development of low-cost and lithium-metal stable halide solid electrolytes for high-performance all-solid-state batteries

Conventional Li-ion batteries using liquid electrolytes (LEs) are suffering from insufficient energy density and safety issues when used for the flourishing market of electric vehicles (EVs). Replacing LEs with solid-state electrolytes (SSEs) to fabricate all-solid-state lithium batteries (ASSLBs) has been regarded as an essential route to improve energy density and safety. Basically, a qualified SSE requires high ionic conductivity and electrode compatibility. Halide SSEs become attractive due to their decent ionic conductivity and good cathode compatibility.

Workforce retention strategies for RPNs within the home and community health care sector

The current nursing shortage in the home and community care (HCC) sector is cause for concern. The demand for home care services is greater than what organizations can provide, especially during the COVID-19 pandemic, leading to high turnover rates.

Effectiveness of Pharmacogenetic testing in improving pharmacologic treatment for CAF Veterans

Advances in the field of pharmacogenetics have brought much attention to the potential benefit of personalized medicine in the field of psychiatry. We will assess the value of a simple pharmacogenetic test for treatment-seeking CAF veterans. If the results from prior depression studies hold in our PTSD population, this approach holds potential to save time and money and accelerate the path to recovery by matching treatment to the profile of each patient, and therefore improving treatment outcomes (Hall-Flavin et al., 2013).

TAT-tagged active AKT1 variants for delivery to mammalian cells

The oncogenic kinase AKT1 is a prime therapeutic target, but its function cannot be easily researched as AKT activation in cells requires stimulation of cells with an unspecific growth factor that alters all cellular signaling. I designed a new method to deliver an already activated, phosphorylated AKT1 protein to cells that do not require the use of unspecific kinase activation or cell-damaging costly transfection reagents.

Developing novel patient-derived xenograft models of glioblastoma using the SRG rat platform

Glioblastoma (GBM) is the most common and deadly cancer arising from the adult brain. There is no effective treatment and a vital need for new, accurate biological models to understand the character and reveal new possible therapeutic strategies. The mouse has long been used to model human GBM, but the very small anatomy creates many limitations. Hera Biolabs has created the SRG rat with brain volume about 5 times those of mice. This proposed study will evaluate the growth of human GBM in SRG rats and the treatment response in this new model.

Development of a Digital Co-care System for the Management of Parkinson’s Disease

There is no cure for PD. Limitations of the current Canadian health care environment, compounded by the effects of the pandemic, have led to infrequent and imbalanced access to care for PwP, which may contribute to inaccurate assessments, incorrect medication dosages, and undermanaged disease symptoms. To improve the lives of PwP, a chronic disease management and monitoring system is needed that involves the patients, their caregivers, and clinicians.

Integration of dynamic imaging and symptomology to identify precise treatments for knee osteoarthritis

Knee osteoarthritis (OA) can present in different ways. The relationships between the symptoms and their causes are mostly unknown, making it difficult to choose the best course of action. Being able to identify various contributor to symptoms would be extremely beneficial to determining the optimal course of treatment. We will develop a system that accounts for 3D joint movements, forces, and their relationships to symptoms using state-of-the-art technology.

Sales Micro-Patterns: ML-driven detection of deviant Store/SKU sales patterns

For almost a century, Canadian Tire has been offering products and services to help Canadians with the jobs and joys of life in Canada. Today, with a network of over 1,700 retail locations, Canadian Tire is dedicated to improving products and services offered to the community they serve. With this project, the company aims to examine the patterns of sales among its stores to identify anomalous product sales patterns. The objective is to design and develop a system capable of generating high-confidence automated notification to the stores.

New technologies for low frequency photoacoustic imaging

This project is focussed on developing an optical imaging technology called photoacoustic imaging. Photoacoustic imaging is able to distinguish healthy tissue from cancerous tissue during breast surgery and could one day eliminate the need for repeat surgeries. The technology uses a pulsed laser to selectively build up pressure in some tissues and microphones to listen for sound as the pressure dissipates. After reconstruction, the sound recordings are converted back into a pressure map representative of the tissues. The project funds will support two PhD students.

Development of Innovative Anaerobic Digestion Technologies for Enhanced Energy Recovery from Cattle Manure

This project explores the use of new anaerobic digestion technologies such as the vacuum-assisted anaerobic digestion as well as innovative pretreatment technologies including the high-shear thermo-alkaline Lystek process and other mechanical, thermal, and chemical pretreatments to enhance the solubilization of the lignocellulose in cattle manure. Enhanced solubilization will result in higher biomethane yields and faster kinetics, resulting in smaller and more efficient farm digesters.