Patients with low kidney function need to take certain medications at a lower dose because their kidneys cannot filter the medication as well from the body. Taking medications at a high dose may be harmful to a patient and lead sometimes to death. The aim of my research is to help reduce medication errors in patients with low kidney function. I will do this by conducting several large studies to determine optimal medication dosing for patients with low kidney function.
The Lockport Group is a succession of carbonate rocks that subcrops in southwestern Ontario. It is of great interest as a source of potable water at shallow depths in Wiarton-Guelph-Hamilton area, of production of oil/natural gas and storage of natural gas and as a hydrochemical indicator interval for potential disposal of nuclear wastes in the deep subsurface. Recently, the Oil, Gas and Salt Resouces (OGSR) Library has published a database of over 28,000 analyses of porosity and vertical and horizontal permeability from 491 wells.
Frequency Selective Surfaces/Structures (FSSs) have great potential to be a mean for improving the capability of communication with Radio Frequency (RF) signals. Although the printed circuit board (PCB) technique is widely available for fabricating FSS, it is difficult to implement using flexible substrates. Its routine process is tedious, costly and environmentally harmful. Other emerging techniques using nano-particle inks also inherently involve large challenges, such as pre- and post-processing, dispersion, agglomeration, and final cost.
Tornadoes are the most disastrous, violent and lethal wind events in the world. In the United States, more than 4,000 fatalities and US$20 trillion in damages were reported between 1950-1994. Recently on September 21st 2018, an outbreak of six tornadoes devastated the Ottawa-Gatineau area in Canada causing damages that might approach US$100 million. Due to the rise in tornado events in recent years, it is expected that the insurance industries and home owners will be more interested in tornado risk mitigation.
Economic development often has dire consequences for wildlife and environmental conservation. In Taiwan coastal waters, a small dolphin population is being affected by large-scale habitat loss and degradation resulting from development projects, pollution, vessel traffic and a massive fishing industry.
In the steelmaking industry, process control models need to be based on a sound physical understanding of the process but should also account for many uncertainties due to the nature and complexity of the environment in which the process is carried out. As a result, it is crucial to extract useful process control information from the raw data stream acquired by the industrial sensors.
Solids exist as crystals, amorphous or subcooled liquids. The degree of crystallinity determines the long range order in a solid phase. Molecules when transferred from the solution to the solid phase may take many different crystal forms (polymorphs, solvates/hydrates, salts, co-crystals). Theoretically, there are 230 space groups describing the diversity of a crystalline material. About two thirds of pharmaceutical small molecules exist in more than one polymorphic solid form. Crystallization of polymorphs still has a touch of art.
Helicobacter pylori (HP) is a bacterium that causes 65% of gastric ulcers and cancers worldwide. Current anti HP treatments often fail because the bacteria have become resistant and they have serious side effects. We are looking into using molecules produced by bacteria called Lactobacilli that are a natural component of the human gastro-intestinal flora to treat and/or prevent Helicobacter infections. The novelty of our approach is to focus on the molecules that Lactobacilli release (i.e. their secretions) and that could be administered to patients in a controlled and reliable manner.
Approximately 5% of the population has a Spondylolisthesis (one of the lower vertebrae slips forward onto the bone directly beneath it). Non-invasive image-based assessment of this spinal structure is an increasing demand in healthcare service. However, the massive information embedded in the increasing large imaging scans has made manual inspection a lengthy and tedious task and observer dependent. The proposed research aims at a computer-aided spinal-scan assessment software toolkit facilitating the diagnosis of Spondylolisthesis.
Global population growth, urbanization and changing climate patterns have increased the demand for potable water, wastewater reuse and value recovery from wastewater, and for remediation of industrial process water. Population growth also results in increased demand for the shipping of goods by ocean freight, with the associated risk of the transport of unwanted marine life from one location to another by the discharge of ballast water.