Dry powder coating of solid pharmaceutical dosages

Solid pharmaceutical dosage forms such as tablets and beads used in capsules are currently coated by liquid coating technology, which incurs high environmental risk and high capital and operation costs. Prof. Zhu's research group has developed an ultratine powder coating technology for the auto industry. Our previous studies have shown that the same technology can also be extended for pharmaceutical solid dosage forms. So far, first success in the new coating technology has been achieved and several coating systems have been developed using acceptable formulations.

Monolithic Integration of Sheath-less Piezo-resistive Pressure Sensor with Volume Conductance Catheter

Scisense is a medical device company focused on Micro Sensor technology used to monitor cardio dynamics in animals as small as mice. Scisense's existing production process l-Or building the micro sensor probes is a tedious process that requires a high degree of skilled labour and ultimately results in a low yield of marketable devices. The company's growth is limited by this yield potential.

Developing an on-line fluidization analysis probe

The main objective of this research is to develop an on-line fluidization analysis probe to be applied on a commercial fluidized bed. This project will focus on a combination of pressure differential and fiber optic reflection probes. Key objectives will be to establish a lab probe with dual fiberoptic and high frequency pressure readings.  Emphasis will be on establishing signal analysis for both fiber optics and pressure and then use the combined probe in a lab environment.

A phase-type model for health status transitions

The main objective of the proposed research is to develop a flexible and mathematically tractable disability model.  The model will describe the rates of transition between health, disability, and death, allow one to explore factors affecting disability incidence and duration and their trends, and facilitate the computation of probabilities associated with future disabilities.  This model will be valuable to London Life, as they have significant amounts of both individual and group disability insurance in force.  The model will provide a tool for analyzing their experience, pricing their di

A Human-Friendly Magneto-Rheological –Based Robot

The objective of the proposed research is the development of a new type of industrial robots that are capable of safely interacting with humans. These new robots are expected to transform industrial automation by providing a robotic platform that allows integration of man and machine in a safe and functional manner. Our main challenges are to meet the strictest safety standards using technologies that render industrial robots qualified for entering human workspaces and at the same time provide a cost effective and intuitive means of interaction with the robots.

Performance of Micropiles System

The methodology assigned for this research depends on two primary elements; field load test on hollow thread bar – self drilled- micropiles and numerical analysis using 3D FEM. The aims of this research program is to capture the actual behavior, load transfer mechanism, ground/grout bond strength, and modes of failure of single micropiles and micropile groups under different types of loading. A site investigation is required for the field tests. The field load tests are characterized by heavy geotechnical instrumentation for the tested micropiles.

Lagrangian Actinometry for UV Disinfection Applications Involving Low-Transmittance Liquids

Ultraviolet photoreactors are commonly used to disinfect drinking water and wastewater. Recently these reactors have been proposed for treating liquid foods such as dairy products, which are much more opaque. The performance of a UV reactor is related to the distribution of UV dose delivered by the reactor. UV-sensitive microspheres have recently been demonstrated as a way to quantify the UV dose distribution in conventional reactors, but have never been used in liquid foods, which present new challenges.

The Use of Transgenic Plants and the Chloroplasts of Green Algae to Produce Low-cost Oral Therapeutics for the Treatment of Type 2 Diabetes

Diabetes is a serious, common and chronic health problem. In Canada, more than 2 million Canadians are living with diabetes today. Type 2 diabetes is the most common type of diabetes that accounts for approximately 90% of diabetes cases. The cost of diabetes care is almost 4 times as much as for someone without diabetes. The Canadian Diabetes Association estimates that the total cost of diabetes will continue to escalate and could reach $15.6 billion by 2010 unless dramatic actions are taken.

Computation of Risk Measures via Efficient Least-squares Monte Carlo

The computation of risk profiles for financial products and portfolios is an extremely important problem, both for regulatory and internal management purposes. For complex products whose value depends on a number of underlying risk factors and for which exercise decisions can be made prior to maturity, Monte Carlo simulation techniques are the only viable procedures. This project aims to adopt a simulation method used for pricing products, to computing risk exposures. Various ways of improving the computational speed will be explored.

Novel RF Coil Design for Parallel MRI of the Breast

This project will be focused on the testing of the performance of a new type of parallel RF coil system that allows for significantly higher signal to noise and imaging performance than currently available coil systems (estimated 3 times higher signal to noise and acceleration of imaging times by a factor of 8-16 times). The coil system which will be tested is a breast imaging coil designed for operation with a 3T GE DVMR imaging platform. The coils to be compared are designed with 8 channel, 16 channel and 32 channel coil arrays.