Characterizing the Immune Response to Novel Vaccine Candidates in a Human Whole Blood Assay Using High-Dimensional Single Cell Proteomics

Monitoring the immuno-modulatory effects of vaccine formulations is critical for novel vaccine development. While animal models have been effective, increasing evidence suggests differences when translating to humans. We have designed a platform which uses fresh human whole blood coupled with a high-throughput single cell analysis, mass cytometry (CyTof Helios), to characterize and model the immune responses to vaccine formulations.

W?SÁNE? Law and Governance: Marine and Terrestrial Management in the Southern Gulf Islands

The proposed research project will explore the question: How can existing mechanisms (National Marine Conservation Area Reserve (NMCAR), Indigenous Protected and Conserved Areas (IPCA), and Management Agreements with Parks Canada in the Southern Gulf Islands (GINPR)) be used to uphold Indigenous W?SÁNE? laws, governance structures, values, and responsibilities within W?SÁNE? territory? Exploring the benefits, limits, and processes for funding, establishment, and enforcement of these mechanisms will help the W?SÁNE?

Wide-baseline Novel Scene Synthesis from a Single Image

Novel view synthesis is the process of generating new images from an unseen perspective, given at least one image of a scene. There may be more than one probable novel view associated with each unseen perspective, an assumption made by existing methods. This simplifying assumption prevents these methods from being applied to more difficult novel views where the set of probable novel views is highly varied. This project proposes to investigate a new approach to generate a wide variety novel views from a single image, and can produce multiple probable outputs.

Intelligent control of space cameras

The intelligent control of space cameras project is concerned with development of the next generation of space cameras. Currently, there is a large gap between the onboard capabilities of standard commercial cameras and those currently in space (examples include image resolution, onboard storage, advanced scene understanding and exposure control).

Cracking the code of financial success

With the cost of living sky-rocketing and incomes lagging, it’s no wonder why people are anxious about their financial futures.

No one teaches you this stuff in high school. But there will soon be an app for that, thanks in part to recent York University research funded by Mitacs.

“Most Canadians don’t have a tool to optimize their investments and only the wealthiest Canadians have access to professional financial advice. But everyone needs a solid plan for retirement,” says Dr. Michael Chen, Professor of Mathematics at York University.

"Virtually" connected: Can virtual reality technology foster closeness and intimacy in romantic relationships?

Social connections, especially satisfying romantic relationships, are vital for health and well-being. Yet, couples are spending increasingly more time apart, limiting opportunities for connection and intimacy. However, engaging in shared novel activities (i.e. self-expanding activities) can help couples connect and maintain their relationship over time. Indeed, couples who experience more self-expanding opportunities in relationships feel closer to their partner and are more satisfied and connected in their relationship.

Examination of beneficial effects of copper fabric on cardiometabolic status, and mechanistic role of gut microbiome

Copper has long been proposed to have important biological properties. Designed to deliver the health benefits of copper, CuTEC yarn is a USPTO|EPO patent pending, bio-engineered copper-based yarn that can be produced as products such as clothing and mattress ticking. Although many believe in the positive properties of copper for well-being, many remain retiscent to believe strong anecdotal evidence with regards to benefits of exposing skin to a pure metal or metal alloy.

3d density estimation using normalizing flows and its application to 3d reconstruction in cryo-EM

Generative models enable the researchers to address multiple problems spanning from noise removal to generating novel samples with properties of the domain. Generative models are commonly studied for images and in this project the idea will be expanded to 3D structures or volumes. Single-particle cryo-electron microscopy (cryo-EM) is a technique to estimate accurate 3D structures of biological molecules which is used by practitioners in fields like precision medicine. This allows them to design drugs that could cure patients with rare diseases and avoid side effects.

Innovative app enables accessible buildings

Ishita Saraswat, a senior undergraduate student from Dayalbagh Educational Institute Dayalbagh, Agra in India and her Tunisian peer, Aymen Brahim from the University of Sfax’s National School of Electronics and Telecommunication (ENET’COM)are Mitacs Globalink Interns who have discovered that the best approach is to identify the problem and implement the solution at the same time via an online app.

Transcriptomics as an Adventitious Virus Detection Strategy

As an analytical platform, the Sanofi Pasteur Analytical Sciences (Toronto) Molecular Biology Centre (MBC) is applying and optimizing the use of high-throughput sequencing (HTS). The detection of adventitious viruses in biological products relies on a set of methods defined by the regulatory agencies called the compendial methods. High-throughput sequencing has the potential to improve the current breadth of detection and to remove some poorly performing compendial in vivo animal tests.

Since 2016, the Molecular Biology Centre has used HTS for the detection of adventitious viruses.

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