The importance of Adiponectin signaling during cardiac remodeling

Many reports have established a correlation between obesity and diabetes with cardiovascular complications such as heart failure. This occurs due to changes in the structure and function of the heart, yet the precise mechanisms responsible for regulating these changes in diabetes remain to be determined. This project will focus on the role played by a substance (adiponectin) which is released from fat cells. Upon release, adiponectin can travel in the bloodstream to have effects in the heart.

Multiscale Data Assimilation and Modeling for Nowcasting and Beyond Year Two

Nowcasting encompasses a detailed description of the current weather along with forecasts during the next several hours. Most current nowcasting techniques, such as MAPLE (the McGill Algorithm for Prediction by Lagrangian Extrapolation) used in The Weather Network/Pelmorex Media Inc., are based on temporal extrapolation of radar and satellite imagery. Recent advances in observation networks, high-resolution numerical models, and in particular the data assimilation methods have great potentials to improve nowcasting accuracy.

Effect of influenza vaccination with high-dose antigen on geriatric population

Vaccination is an important preventive measure against influenza infection during both seasonal epidemics and pandemic outbreaks. This research aims to evaluate the health benefits and costs associated with a new vaccine developed by Sanofi for seasonal influenza. This vaccine provides better efficacy and higher protection for individuals over 65 years of age. The vaccine is expected to reduce severe illness and hospitalization in this age group.

Keyword Search in Relational Databases for Business Users

Much of the world's high-quality data remains under lock in relational databases. Access is gained through relational query languages. This can suffice for people who are well versed in both SQL and in the schemas of databases. However, anyone who does not know SQL or who is not well versed in the schema is effectively locked out. Keyword search over relational databases was proposed a decade ago to offer an alternative way to query a database. While the general approach has merit, many refinements are needed, before it can be an effective product.

Multiscale Data Assimilation and Modeling for Nowcasting and Beyond

The strategic plan is to improve storm nowcasting by using an advanced multiscale data assimilation and modeling system.

How Teachers Understand Self-Regulation: Connecting the Canadian Self-Regulation Initiative with Pearson Canada Inc

The notion of ‘self-regulation’ in the development of children and young people and the health of adults has taken on considerable importance, especially in education, as the science investigating this feature has made significant advances over the last decade. One nationwide initiative, the Canadian Self-Regulation Initiative (CSRI), has been working since 2012 to support educators’ understanding about self-regulation and their ability to integrate these ideas into their practice.

ExomeAnnotator: Developing a system biology approach to genome annotation for disease risk assessment

Understanding the underlying factors that cause inherited diseases to develop is an important step in improving the health status of individuals, and identifying effective prevention and control measures. This project aims to apply fundamental know of genetics, genome sequence analysis, modeling and simulations, and bio-informatics to uncover the relationship between these factors and assess the risk of such diseases.

Why Galaxies Spin

Our galaxy the Milky Way and our orbiting companion Andromeda are the dominant members of a small collection of galaxies, the Local Group, which is about 3 million light years across. Recently, it was recognized that the Local Group is simply a mass concentration in a thin "Local Sheet" of galaxies spanning 35 million light years. Furthermore, the largest members of the Sheet encircle us. This unusual environment may have played a role in guiding the evolution of the Local Group, and the Local Group may have influenced the evolution of the Local Sheet.

Flocking behavior research

Flocking behavior is the behavior exhibited when a group of birds, called a flock, are foraging or in flight. There are parallels with the shoaling behavior of fish, the swarming behavior of insects, and herd behavior of land animals. What we want to do is to build the mathematics models and use these models to describe the flocking phenomenon. Many mathematics scientists have made great contribution to study the flocking phenomenon. We will use the knowledge of the differential dynamical system to study it.

Economic capital and capital allocaton modeling

The International Association of Insurance Supervisors, of which Canada is a member, has recently introduced the notions of Enterprise Risk Management (ERM) and Own Risk and Solvency Assessment (ORSA), as two key components of its regulatory reform. Loosely speaking, the ERM identifies, measures and monitors insurer risks while the ORSA manages them.