Evaluation of a radiomic approach based on hyperspectral retinal imaging to predict the cerebral amyloid status for the diagnosis of Alzheimer’s disease

The project will help Optina validate and further develope a novel technology to predict the presence of significant amyloid (A?) deposition in the brain from a simple, non-invasive hyperspectral retina scan in combination with an artificial intelligence algorithm. Accumulation of A? plaques in the brain is a key hallmark of Alzheimer’s disease (AD), but current methods to evaluate its presence in vivo (A? positron emission tomography imaging and quantification of A?

Tuning in to emotions of non-communicative persons

Many individuals who have severe disabilities or who have suffered traumatic injury are unable to move or speak, and hence, unable to communicate with their family and caregivers. The physiological systems of these individuals are typically functional and can change to reflect the unexpressed mental and emotional states of these otherwise non-communicative persons. In this project, we will design an exhibit which will collect data to generate an emotion classifier using changes in autonomic nervous system signals patterns.

Implantation et validation d’une nouvelle approche de navigation chirurgicale en chirurgie orthopédique

Malgré la précision inhérente des éléments matériels des systèmes de navigation chirurgicale existants, la façon dont ils sont couramment utilisés en chirurgie orthopédique introduit une imprécision en limitant l'intérêt clinique. Les chirurgies pratiquées comportent des étapes importantes pouvant bénéficier d'un guidage fiable et reproductible pour leur réalisation afin d'en optimiser le résultat, entre autres en rétablissant une fonction articulaire plus proche de celle d'une articulation en santé.

DLVR Drug Delivery Characterization

Highly targeted therapies can be devised to treat a variety of cancers, specifically acting on the mutated genes causing tumor growth. One challenge with such techniques is delivering the therapy to the interior of the cancer cell, when enzymes in the blood can actively break down the therapeutic molecules or when delivery to healthy cells can cause toxicity. Nanoparticle carrier molecules can solve this problem by containing the payload and delivering it directly to the cancer cell.

Optimization of a Dermoskeleton for Human Performance in Clinical and Occupational Applications

Physical disability in Canadian adults is largely due to painful mobility impairments, with the most common cause being diseases of, and injuries to, the musculoskeletal system and connective tissues (MSK disorders). MSK disorders are generally associated with natural aging, but are also caused by occupational injuries as well as brain or spinal cord injury or disease. The cost of these conditions to the Canadian Health Care system is in the tens of billions per year.

Testing of Fibre Properties for their Biomedical Applicability

Natural fibres have been used in many industry sectors such as automobiles, aerospace, construction, etc., but their use in the biomedical industry is relatively new. The major obstacle to their use is the lack of information on relevant fibre properties. This project focuses on testing three critical properties: antimicrobial properties, antioxidant properties, and water sorption in flax, hemp, canola, and sweet clover fibres. Testing these properties will be a stepping stone for proving the applicability of natural fibres in biomedical applications.

Systems and methods for planning and guidance ofneurosurgical procedures

Synaptive Medical Inc together with researchers at Western University, are developing a new Magnetic Resonance Imaging (MRI) platform customizersd for clinical neuroimaging. This proposal is to fund a range of student and post-doctoral training activities associated with the development and testing of this new system. The program will also support the development and testing of MRI-compatible devices and technology for use with the new platform.

Reducing daytime leg fluid accumulation using electrical stimulation of the legs to decrease overnight rostral fluid shift and consequent sleep apnea

Obstructive sleep apnea (OSA) is a common disorder affecting 6% of the adult population and increases risk of cardiovascular mortality. OSA occurs due to repeated full or partial collapse of the upper airway during sleep. One contributor to airway collapse during sleep is the overnight shift of fluid from the legs towards the neck where it accumulates. Increased daytime fluid accumulation in the legs magnifies this, resulting in more fluid accumulation in the neck and increased OSA severity.

Role of nocturnal fluid redistribution in the pathogenesis of sleep apnea Year One

when lying down to sleep and accumulates in the neck or lung; which could be a major contributor to the development of sleep apnea in HF patients. Therefore, we aim to determine whether: 1) the relative degree of fluid shift into the neck and lungs at night is associated with the severity of sleep apnea; 2) the respiratory sounds recorded from the neck and lungs can be used to estimate the amount of nocturnal fluid accumulated in the neck or lungs. If so, a new approach for the therapy of sleep apnea would be to prevent fluid accumulation in the legs during the day.

Development of Fast Longitudinal Cortical surface extraction, deformation, and Normalization (FALCON) for the measurement of cortical thickness over time from brain magnetic resonance images Year Two

The project involves development, validation, and application of new medical image analysis algorithm where cortical thickness is measured from serial brain magnetic resonance imaging (MRI) with improved efficiency and greater sensitivity. Cortical thickness is a relatively new metric that correlates with clinical and cognitive worsening in a variety of neurologic disorders such as multiple sclerosis and Alzheimer's disease.

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