Optimizing medical marijuana: developing genetic and chemical resources to improve the quality and quantity of cannabinoid metabolites in Cannabis sativa L strains

Cannabinoids are synthesized and accumulate in Cannabis plant hairs called glandular trichomes, which are particularly abundant on female flower buds. Cannabinoid content and composition vary dramatically among Cannabis strains, with two general groupings distinguished: marijuana strains, defined by high THC and low CBD levels, and hemp strains containing low THC and high CBD (or low total cannabinoid content).