Non-Viral delivery of insulin and IL-10 to the intestine for immunotherapy for type 1 diabetes

There is increasing evidence suggesting a link exists between the gut immune system and several autoimmune diseases, including diabetes. The industrial partner of this project, enGene, has developed an effective non-viral based technology for the delivery of genes to the intestine. enGene has demonstrated the feasibility of delivering IL-10, which is an anti-inflammatory cytokine, to the intestine and showed therapeutic efficacy in inflammatory bowel disease.

Gut-localized expression of IL-10 for the treatment and/or prevention of peanut allergy

We will evaluate treatments for peanut allergy, the most severe and persistent form of food allergy. The proposed interventions are based on targeted delivery of interleukin-10 (IL-10) to the intestine. IL-10 is a protein that is known to be a potent regulator of the immune system. enGene has developed EG-10, a novel, state-of-the-art technology that can effectively induce a robust and transient production of interleukin-10 in the intestine, i.e., the site where food absorption occurs and food allergy is initiated.

Non-Viral delivery of insulin and IL-10 to the intestine for immunotherapy for type 1 diabetes Year Two

There is increasing evidence suggesting a link exists between the gut immune system and several autoimmune diseases, including diabetes. The industrial partner of this project, enGene, has developed an effective non-viral based technology for the delivery of genes to the intestine. enGene has demonstrated the feasibility of delivering IL-10, which is an anti-inflammatory cytokine, to the intestine and showed therapeutic efficacy in inflammatory bowel disease.

Transfert d'un gène non viral aux cellules souches de l'intestin

Ce projet de stage vise à produire une protéine d'amaigrissement capable de combattre l'obésité. Le stagiaire recouvrira l'ADN de la protéine d’une substance naturelle pouvant être administrée par voie orale ou par chirurgie. Si l'expérience réussit, l'équipe s'attend à constater la présence de la protéine d'amaigrissement dans le sang des spécimens. De plus, les niveaux devraient augmenter après les repas, ce qui devrait réduire l'appétit et favoriser la perte de poids.