Development of an Integral Strategy for Model-based Dose Adaptation in Chemotherapy
The overall objective of this PDF project is to propose an integrated dose adaptation strategy that can be used in anticancer drug treatment. Indeed, many chemo agents used to treat tumors often induce dangerous side effects or toxicity, such as neutropenia [Crawford et al.] and hand-foot syndrome [Janusch et al.]. Since some tumors can only be destroyed by sufficiently high doses of chemotherapeutic agents, these harmful and lethal toxicities have become a main obstacle that limit the full use of the dosage of anticancer drugs or even force the discontinuation of chemo treatment. A rational dose adaption strategy that can enhance the drug efficacy while minimizing toxicity will greatly increase the treatment success for the benefits of patients and health care systems. Because of the complexity of chemotherapy and difficult conditions for data collection, mechanistic based modeling approaches have been considered one of the main solutions to this puzzle [de Jonge et al, Wallin et al, Vainas et al, Paule et al]. Depending on data availability, different modeling approaches have been proposed for a better control of toxicity without interrupting the chemo treatment.