Development of a programmable and highly specific anti-bacterial synthetic live biotherapeutics
Antibiotic resistant bacteria are one of the major threats of the 21st century. These superbugs, which are resistant to virtually all our antibiotic arsenal, can turn benign infections into life threatening diseases. It is estimated that, by 2050, the death toll associated with antibiotic resistant infection will rise to 10 million people. We thus need to act now and develop alternative technologies that can replace conventional antibiotics in order to prevent this crisis.
This project proposes a totally new approach to eliminate antibiotic resistant bacteria. Instead of using molecules to kill bacteria, we propose to use engineered probiotics. These probiotics can recognize and eliminate specifically antibiotic resistant bacteria. This therapeutic breakthrough approach turns superbugs into regular bugs that we can eliminate.