Does multimodal prehabilitation reduce cardiovascular complications in high-risk surgical patients? A pilot randomized controlled trial.
Cardiovascular complications after major surgery, such as death, heart attack and stroke, contribute significantly to perioperative morbidity and mortality. Patients at high-risk of complications after surgery can be accurately identified by measuring brain-natriuretic peptide (BNP) in the blood, however limited interventions exist to reduce their risk of complications and improve their recovery. Prehabilitation is an emerging concept that aims to optimise a patient’s physical, nutritional, and mental health prior to major surgery in order to improve postoperative recovery. We propose a pilot randomised controlled trial assessing the impact of 4-week multimodal prehabilitation program, compared to standard of care, on postoperative cardiovascular complications among high-risk surgical patients. By examining postoperative complication rates (such as stroke, heart attack, and death) in both groups, we aim to identify whether prehabilitation is an effective strategy to improve patients’ recovery and reduce surgical complications.