iPSC derived 3D muscle engineering

Myopathies are a group of muscle diseases that are caused by over 150 genes variants, leading to muscle weakness and/or wasting. In addition to the emotional, physical and social impact on the patients and their families, the medical expenditure for the patients affected by myopathies is substantial, about $7.2 billion in Canada, which makes it the 4th diagnostic category with the largest total cost for the healthcare system. In a collaboration with the eNUVIO bio-engineering company, we aim in this project to develop a 3D engineered skeletal muscle tissue from patients derived iPSC for disease modeling and drug screening, which could lead to the development of new tools that improve patients care and decrease the economic burden of these diseases.

Zakaria Orfi
Superviseur universitaire: 
Nicolas Dumont
Partner University: