Screening of bacteriophage receptor on mutant bacterial libraries

Phagelux has developed a cocktail of bacteriophages (bacterial viruses) that treat infections with bacteria resistant to antibiotics. During the curse of treatment, bacteria may become resistant to bacteriophages included in the cocktail. This project aims at determing the bacteria surface markers on which bacteriophages can bind and start their therapeutic function. This will help Phagelux to improve the cocktail by adding other bacteriophages that can bind on other surface not targeted by the bacteriophages included in the existing cocktail. This will enhance the cocktail potency and will be beneficial to patient suffering infections with bacterial resistant to antibiotics.

Simon De Grandpré
Superviseur universitaire: 
Hugo Soudeyns
Partner University: