Inverse Drug Design via Multi-Objective Curriculum Learning

The project involves the development of an algorithm to generate organic molecules that satisfy desired properties and characteristics defined by a medicinal chemist.

Identification et prévention des risques en santé et sécurité du travail pour les conducteurs de véhicules transportant des matières dangereuses

Ce projet va chercher à identifier les facteurs liés aux travailleurs, à l’environnement immédiat de travail et au contexte organisationnel qui peuvent augmenter la probabilité qu’un incident ou accident survienne avec des conducteurs. Une approche multidisciplinaire de la SST (incluant, l’ergonomie, la psychologie des comportements humains, l’ingénierie des facteurs humains et le management de la sécurité), est mise de l’avant et ce, tant au niveau du diagnostic organisationnel que des solutions apportées.

Design and Synthesis of Specific Inhibitors of CYP26 for Blocking Retinoic Acid Metabolism: A Safer Approach to Retinoid Therapy for Skin Disease Year Two

Acne is a common human skin disease which is highly prevalent during adolescence, and often continues into adulthood. Retinoids, such as isotretinoin (Accutane/Roaccutane), have been particularly effective systemically in the treatment of acne. Although, millions of patients have been treated with Accutane/Roaccutane which for many years generated more than $1B U.S. in annual sales, the side effects, such as birth defects and inflammatory bowel disease, can sometime be severe. The market opportunity of an effective treatment with a better safety profile than isotretinoin is significant.

Development of a microbe granulation technology for the increased treatment of organic wastewater, removal of emerging containments and digestion of sludge

Today we are failing to properly and completely treat organic wastewater which results in large amounts of sludge buildup and many untreated emerging contaminates that are shaping and changing our environment. If we ignore this problem: we will see an increased need for resources to development new and very expensive mechanical processes to manage sludge, wildlife will experience further side effects, and the appearance of emerging containments that are causing additional side effects to the surrounding population will also continue to increase.

Tumor Reduction and Enhanced Responsiveness to Radiation Therapy and Chemotherapy Via Selective Removal of Iron: Mechanism and Preclinical Evaluation Year Two

Chelation Partners Inc. has developed a family of new and highly selective iron chelators such as DIBI. In collaboration with Dr. Hoskin, DIBI is being investigated as a novel anti-cancer agent. Preliminary research suggests that DIBI can selectively inhibit the growth and survival of cancer cells and render them more sensitive to radiation therapy. The proposed research builds on previous work to increase our understanding of how the removal of iron by DIBI affects cancer cells and makes them more sensitive to radiation and/or chemotherapy.

Removal of Volatile Organic Compounds (VOCs) and Ozone (O3) from Gas Emissions

Volatile Organic Compounds (VOCs) generally refer to hydrocarbon solvents. VOCs emissions are air pollutants that give rise to deleterious health and environmental effects. VOCs are about 11 times more effective green house gases than carbon dioxide (CO2) (Reijo, 2010). VOCs react with oxides of nitrogen (NOx) to form Ozone (O3) which contributes to Green House Effect (GHE). Therefore, government has enforced regulations to limit the VOCs emissions. The target is to convert all VOCs (99%) to water and CO2 and Ozone (99%) to molecular dioxygen.

The Utilization of Bark to Make Rigid Polyurethane Foams

Polyurethane foams are so commonly used, from rigid dashboards in cars, to insulation in buildings, and the comfy mattresses we sleep upon. Replacing the petrochemical resources used to make them with renewable resources like bark would be a great stride towards sustainability. In order for this to be done the conversion process of bark into a liquid must be better understood. This project will try to elucidate how alcohols interact with the bark to digest it during the conversion process.

Étude de la valorisation du lixiviat d'ensilage de résidus de cultures agricoles commeingrédient ou produit biosourcé

Nethasol est une entreprise du secteur des nouvelles énergies et de l’environnement qui évolue au sein des entreprises agricoles. Cette dernière a mis au point une technologie de captation du sirop noir généré par les techniques traditionnelles d'ensilage en silo. Actuellement, tous les silos ont un drain permettant l’écoulement de ce déchets agricoles (sirop noir) vers les faussés de campagne. Or, grâce à la technologie et aux installations de Nethasol, il est possible de recueillir près le sirop noir pour une installation d’ensilage moyenne.

Characterization and Improvement of Interfacial Properties of Cathode Materials forRechargeable Hybrid Aqueous Batteries

A new aqueous rechargeable battery combining an intercalation cathode with a metal anode has been developed recently. The energy density for a prototype battery is comparable or superior to commercial 2 V rechargeable batteries. There is a need to further improve the cycle performance and to reduce self-discharge effects of this battery. In this proposed research, novel surface improvements will be applied to the cathode material to improve the overall electrochemical performance of the battery and to improve the stability of the cathode material.

Design and Synthesis of Specific Inhibitors of CYP26 for Blocking Retinoic Acid Metabolism: A Safer Approach to Retinoid Therapy for Skin Disease

OBJECTIVE; We will advance our development of novel specific inhibitors of the retinoic acid (RA) metabolizing P450 enzymes, CYP26A1 and CYP26B1, to treat skin disorders - an approach that will have significant safety advantages over current retinoid therapies. These inhibitors will be used primarily to target cystic acne but will also be evaluated for their therapeutic potential in treating other skin disorders including actinic keratosis, rosacea, oral leukoplakia and skin cancer.