Faire avancer le rétablissement à la suite d’une fracture de la hanche sans une technologie complexe

Dans cette tranche d’âge, environ 50 pour cent des femmes et 25 pour cent des hommes subiront au moins une fracture ostéoporotique subséquente pendant le reste de leur vie. Après avoir subi une fracture de la hanche, le déclin de la mobilité et du fonctionnement des aînés peut être rapide. Il en résulte une dépendance accrue sur les soins, et des fardeaux financiers imposés sur leurs fournisseurs de soins et le système de soins de santé.

The International Dimension of Canada's Museums

Our proposed research seeks to examine the contemporary role of museums, their agency, and international agendas within a cultural diplomacy framework that recognizes the role of non-state actors in international relations. The purpose of this project is to asses how international cultural work is understood by, and at, cultural institutions in Canada.

De la recherche sur les allergies qui n’est pas de quoi éternuer

Cet été, Alexia travaille sur un projet de recherche avec la Dre Anne Ellis du département des sciences biomédicales et moléculaires de l’Université Queen’s. La recherche de la Dre Ellis explore les allergies et leur impact sur la population canadienne. Le projet d’Alexia aidera à déterminer s’il existe des liens entre les quantités de pollen dans l’air local, les allergies d’une mère (ou leur absence) et les biomarqueurs des allergies potentielles des enfants dans le sang de cordon ombilical.

Building on an Innovative Platform: Tuning Guanine Quadruplex Recognition for Anticancer Applications

Beyond the well-known double-stranded helical duplex, DNA can adopt many unusual architectures, including guanine quadruplexes (G4), which in recent years have been implicated in cellular processes that lead to the development of cancer. It has been shown that these processes can be switched off by maintaining the folded quadruplex architecture using chemical compounds known as G4 binders.

La technologie des piles à combustible dans les véhicules du futur

Avec le dévoilement en 2010 d’une flotte de démonstration de véhicules de Classe B alimentés par piles à combustible, Mercedes-Benz s’est imposé comme concurrent clé dans ce marché émergent. La percée est arrivée en réponse à des milliers d’heures de R-D dans la technologie des piles à combustible à l’usine de fabrication pilote de Mercedes-Benz en Amérique du Nord.

Contribuer à la recherche sur le cancer de la prostate au Canada

Cet intérêt pour l’exploration l’a incité à participer au Programme de stages de recherche Mitacs Globalink au Département de physique, de génie physique et d’astronomie de l’Université Queen’s cet été. Sous la supervision du professeur Robert Gooding, Birbal utilise des techniques statistiques pour comprendre la façon dont les facteurs génétiques ou environnementaux peuvent favoriser la croissance de tumeurs aux stades avancés du cancer de la prostate.

State-society relations at the margins: Control and Resistance in Turkey’s borderlands (1990-2004 and 2004-present)

There is a controversial relationship between the levels of democratization and violence. Although it is assumed that more democratic a country becomes less violence occurs, there are some counterarguments (Tezcur 2009). This project is an attempt to test the viability of whether democracy leads pacification. We will compare two time periods to evaluate the impacts of change in state strategy toward Kurds in Turkey’s borderlands. The first is the period from 1990 to 2004, which is a period of military domination. The second time period is commonly associated with political liberalization.

Investigation of In-Situ Flux Effect on Hydride Properties in Zr-2.5Nb Pressure Tubes in CANDU Reactors Year Two

Zr-2.5Nb pressure tubes used in CANDU reactors are susceptible to hydride cracking-induced crack initiation mechanisms, a.k.a delayed hydride cracking or DHC and overload crack initiation. For the integrity assessment of CANDU pressure tubes, it is required to evaluate the likelihood of DHC and overload crack initiation from serviceinduced flaws and to determine whether the pressure tubes are still fit for continued service. The main focus of this proposal is to evaluate the effect of in-situ flux effect on the structure and fracture properties of zirconium hydrides.

Design and Synthesis of Specific Inhibitors of CYP26 for Blocking Retinoic Acid Metabolism: A Safer Approach to Retinoid Therapy for Skin Disease Year Two

Acne is a common human skin disease which is highly prevalent during adolescence, and often continues into adulthood. Retinoids, such as isotretinoin (Accutane/Roaccutane), have been particularly effective systemically in the treatment of acne. Although, millions of patients have been treated with Accutane/Roaccutane which for many years generated more than $1B U.S. in annual sales, the side effects, such as birth defects and inflammatory bowel disease, can sometime be severe. The market opportunity of an effective treatment with a better safety profile than isotretinoin is significant.

Cytokine profile in women with cervical insufficiency

Cervical insufficiency (CI) is a condition in which the cervix prematurely shortens and dilates during pregnancy, typically resulting in mid-trimester pregnancy loss or premature labour. The causes of CI are currently unknown. However, recent studies have associated abnormalities in immune system regulation with pregnancy complications such as spontaneous abortion and premature birth. Since the immune system is regulated by circulating molecules known as cytokines, abnormal cytokine regulation could be associated with these pregnancy complications and with cervical insufficiency.

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