Using Viral Dynamics to Connect Clinical Markers of Disease Progression to Sequence Evolution for HIV-1

HIV-1 remains a global health challenge, with over 35 million people infected. The high rates of turnover and evolutionary adaptability exhibited by HIV-1 pose a particular challenge to the use of antiretrovirals, as well as the development of a vaccine. Our focus is to understand the dynamics of two of the most commonly tracked clinical markers of an HIV-1 infection: CD4+ T cells/mm3 (CD4 count) and HIV-1 RNA/ml (viral load).

Asset-Based Community Enterprise Development in Bolivia

This cross-sectoral research project will track the process of supporting four nascent community-based enterprises (CBEs) in indigenous communities in the Bolivian highlands, examining the complex interaction of factors that contribute to successful CBEs.

Increasing and Automating Adaptivity of LogicBlox Datalog Platform

Declarative programming techniques have been used to make programming available to common users through introducing query languages such as SQL and spreadsheet programs such as Excel. The proposed industrial partner, LogicBlox, has developed software that enables highly-complex data analysis through the flexible and familiar form of spreadsheet computing. The main goal of this proposal is to increase and automate adaptivity of LogicBlox platform, and to evaluate proposed methodology through applications in local industry.

Ancestral aches? An assessment of the relationship between bipedal locomotion, primate vertebral shape and human spinal health

The project will investigate the relationship between evolutionary adaptations to upright posture and the occurrence of common back problems in humans. It will use three-dimensional shape analysis techniques to investigate the vertebral shape of both humans and apes, as well as their fossil ancestors. It will also use motion capture technology to explore the relationship between human locomotion, vertebral morphology, and spinal health.

Flexible and fully integrated power patch for self-powering sensors

Nowadays the most rewarding aspect of engineering is to create solutions to the needs of society in a natural and resource efficient manner, therefore we must come up with more innovative and resource efficient solutions. One such solution can be a novel, flexible and scalable power-patch, which integrates an inductive coupling, a power conversion and conditioning unit and a super capacitor based energy storage system using a state-of-the-art polymer integration and packaging technology.

Managing Knowledge Discovery and Data-Mining Through Visual Analytics, Concept Maps and Ontologies

This research project aims to prototype and evaluate a computer system supporting the creation of data-driven domain ontologies.
The first phase consists in creating a working prototype of a computer application supporting:
1) Preliminary research;
2) Creation of an interactive and visual computer interface allowing the visual concept mapping of a domain, its entities; define relationships between those entities and define attributes and parameters of those entities and relationships;

Investigating Nano-Media in Communications, the Arts and Creative Communities

Investigating Nano-Media develops and disseminates groundbreaking technological innovations in the field of nanooptics and explores the possibilities of a new nano-material--nano-media--for communication, media and art practices. We deploy a pioneering multi-functional nano-fabric that comprises nano-substrates with embedded functionalities and new advanced fabrication processes. This unique nano-fabric is then further augmented by the processes of ‘nanography’ and ‘nano-photography’.

A Bayesian Probability Network Approach To Predictive Modeling in Support of EffectiveManagement of Underwater Noise in Marine Mammal Habitat

Marine mammals have evolved to send and receive underwater sound as their primary means for communicating, finding food, and sensing their environment. Introducing human-generated and other unnatural sources of noise into their environment can cause potentially serious consequences, particularly for those species at conservation risk. Past work on predicting the behavioural response to excessive noise has ignored the variability in the sound field and in marine mammal behaviour.

Impact of chronic exposure to vascular stressors on mitochondrial health and vascular smooth muscle cell plasticity

Blood vessels are made up of specialized cells including the endothelial cells lining the blood vessels and smooth muscle cells (SMCs) that constrict vessels and regulate blood flow. SMCs are constantly exposed to diverse growth factors, hormones and inflammatory signals that affect their phenotype and function. Mitochondria are essential to the normal functioning of SMCs, and aging and inflammation can effect mitochondrial number, structure and function.

Tests for models used in Actuarial and Risk management and Economic forecasting

In Actuarial Science and insurance, models are often used to assess risk using factors such as age, level of education, gender, environment, etc. In practice, there might be unobserved factors.  When data are gathered, the accuracy of these models should be investigated. If the model is not well fitted by the data, subsequent influences could be badly wrong. In this proposal, we shall examine tests to check the model validity. In addition, we examine the effect on inference of a failure in the model.