Investigation of a novel Spatially-Sensitive Transmission Detector for real-time verification of radiation beams during Radiation Therapy

Unprecedented advances have been made in Radiation Therapy during the past two decades. High precision treatment plan is generated using sophisticated optimization methods, and treatment is delivered with complex intensity modulation techniques. Due to the complexity, the burden of Quality Assurance (QA) for modern radiotherapy has also increased dramatically.

Enhancement of a Pharmacogenomic Treatment Decision Support Tool for Schizophrenia

The GeneSight (GS) Psychotropic Test (AssureRx Health, Inc.) measures individual variations in drug-related genes and recommends optimal drug choices for individual patients. A clinical study will be conducted to validate novel gene markers of antipsychotic-induced weight gain for use in an enhanced version of GS. Sarah Groleau will be responsible for genotyping DNA from 600 schizophrenia patients to evaluate which of the significant gene variants (UofT/CAMH) predict the most troubling side effect of antipsychotic medications: weight gain and metabolic syndrome.

Smart Water Distribution Systems to Conserve Energy and Water Year Two

Municipal water supply pumps consume a large amount of energy and have been shown through field testing to operate at efficiencies of approximately 10% less than their original condition on average. A proprietary technique for the optimal selection of pump combinations has been preliminarily developed and can be applied without any capital improvements to the system, but rather just the implementation of affordable sensing equipment and changes to operational logic of the pumps.

Error Resilient Communication and Processing Techniques for Streaming Data Year Two

Emerging applications such as interactive video conferencing, Voice over IP (VoIP) and cloud computing are required to achieve an end-to-end latency of less than 200 milliseconds. In many wireless networks, the round-trip time can alone reach this limit. Hence it is necessary to develop new delay-optimized networking protocols and delay-sensitive coding techniques in order to meet such stringent delay constraints. The proposed project will investigate both theoretical foundations and practical implementations to reduce delays in interactive communication scenarios.

High performance engineered biocomposites for automotive sector

The proposed project seeks to develop biocomposite technology and products for the auto manufacturing industries. Five graduate students under the supervision of Dr.Mohini Sain, will work on manufacturing processes, mechanical characterization, composite rheology and development of molds for various types of bio-composites which have direct application in auto-industries and can act as substitute for fossil fuel based composites. The two partner organizations will be the Centre for Biocomposites and Biomaterials Processing (CBBP), Faculty of Forestry, Univ.

Closing the Gap of Write- vs. Read-intensive Data Stores Using SSDs Year Two

Many big data challenges are characterized not only by a very large volume of data that has to be processed but also by a high data production rate. In this project, new storage approaches for big data will be explored. Key point is the efficient use of modern hardware, especially modern storage technology such as SSDs. These new technologies have highly improved performance in comparison to traditional hardware. However, classical data structures and algorithms can not directly be applied due to the different characteristics of these devices.

The Utilization of Bark to Make Rigid Polyurethane Foams

Polyurethane foams are so commonly used, from rigid dashboards in cars, to insulation in buildings, and the comfy mattresses we sleep upon. Replacing the petrochemical resources used to make them with renewable resources like bark would be a great stride towards sustainability. In order for this to be done the conversion process of bark into a liquid must be better understood. This project will try to elucidate how alcohols interact with the bark to digest it during the conversion process.

Online seizure detection using EEG-based features of neural rhythms measured from a wireless headset

Avertus Epilepsy Technologies Inc. is building a wireless headset that records brain waves (EEG) without requiring extensive, time-consuming, and uncomfortable patient preparation. Avertus’ SMART (Seizure Monitoring at the Right Time) Headset is a patient focused, point-of-care monitoring and detection system. Worn during the day or just at night during sleep, the SMART Headset represents safety, response when needed, and peace-of-mind. For drug companies and treating physicians, the SMART Headset provides an objective measure of seizure occurrence to assess drug efficacy.

Low-power EEG headset for remote monitoring and warning system

Avertus Epilepsy Technologies Inc. is building a wireless headset that records brain waves (EEG) without requiring extensive, time-consuming and uncomfortable patient preparation. Avertus’ headset is a patient-focused, point-of care monitoring and detection system. To design the wireless EEG headset, commercially available dry electrodes will be analyzed and characterized to determine the optimum properties for better EEG recordings. A miniaturized circuit board will be designed for each electrode to make active electrodes that can provide a high quality EEG signal right on the headset.

Metagenomic study of dechlorinating microbial communities invitro and in situ, part 2

The project is focused on study of commercial microbial cultures for biological remediation of soils and ground waters contaminated by chlorinated organic compounds. The successful elaboration and improvement of the products requires analysis on molecular-genetic level and detailed understating of organization of the microbial communities. The work benefits to industry partner by providing comprehensive information on functional and taxonomic structure, metabolic models of the studied microbial communities and key microorganisms involved in dechlorination of chloroform.